Role of TET enzymes in DNA methylation, development, and cancer

The pattern of DNA methylation at cytosine bases in the genome is tightly linked to gene expression, and DNA methylation abnormalities are often observed in diseases. The ten eleven translocation (TET) enzymes oxidize 5-methylcytosines (5mCs) and promote locus-specific reversal of DNA methylation. T...

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Bibliographic Details
Published in:	Genes & development Vol. 30; no. 7; p. 733
Main Authors:	Rasmussen, Kasper Dindler, Helin, Kristian
Format:	Journal Article
Language:	English
Published:	United States 01.04.2016
Subjects:	Animals Cytosine - metabolism Dioxygenases - genetics Dioxygenases - metabolism DNA Methylation - physiology DNA-Binding Proteins - metabolism Epigenesis, Genetic Gene Expression Regulation, Neoplastic Humans Neoplasms - enzymology Neoplasms - genetics Oxidation-Reduction Proto-Oncogene Proteins - metabolism DNA methylation leukemia DNA demethylation hematopoiesis TET; hydroxymethyl cytosine
ISSN:	1549-5477, 1549-5477
Online Access:	Get more information
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