T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants

Cancer immunotherapies, including adoptive T cell transfer, can be ineffective because tumors evolve to display antigen-loss-variant clones. Therapies that activate multiple branches of the immune system may eliminate escape variants. Here, we show that melanoma-specific CD4 T cell therapy in combin...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Cell Ročník 186; číslo 7; s. 1432
Hlavní autori:	Hirschhorn, Daniel, Budhu, Sadna, Kraehenbuehl, Lukas, Gigoux, Mathieu, Schröder, David, Chow, Andrew, Ricca, Jacob M, Gasmi, Billel, De Henau, Olivier, Mangarin, Levi Mark B, Li, Yanyun, Hamadene, Linda, Flamar, Anne-Laure, Choi, Hyejin, Cortez, Czrina A, Liu, Cailian, Holland, Aliya, Schad, Sara, Schulze, Isabell, Betof Warner, Allison, Hollmann, Travis J, Arora, Arshi, Panageas, Katherine S, Rizzuto, Gabrielle A, Duhen, Rebekka, Weinberg, Andrew D, Spencer, Christine N, Ng, David, He, Xue-Yan, Albrengues, Jean, Redmond, David, Egeblad, Mikala, Wolchok, Jedd D, Merghoub, Taha
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 30.03.2023
Predmet:	Animals Antigenic Drift and Shift CTLA-4 Antigen Immunotherapy Melanoma Mice Neutrophils - pathology T-Lymphocytes - pathology OX40 neutrophil extracellular traps antigenic heterogeneity immunotherapy anti-tumor neutrophils CTLA-4 adoptive T cell therapies neutrophils tumor hetergeneity immune checkpoint blockade
ISSN:	1097-4172, 1097-4172
On-line prístup:	Zistit podrobnosti o prístupe
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!