T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants

Cancer immunotherapies, including adoptive T cell transfer, can be ineffective because tumors evolve to display antigen-loss-variant clones. Therapies that activate multiple branches of the immune system may eliminate escape variants. Here, we show that melanoma-specific CD4 T cell therapy in combin...

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Bibliographic Details
Published in:	Cell Vol. 186; no. 7; p. 1432
Main Authors:	Hirschhorn, Daniel, Budhu, Sadna, Kraehenbuehl, Lukas, Gigoux, Mathieu, Schröder, David, Chow, Andrew, Ricca, Jacob M, Gasmi, Billel, De Henau, Olivier, Mangarin, Levi Mark B, Li, Yanyun, Hamadene, Linda, Flamar, Anne-Laure, Choi, Hyejin, Cortez, Czrina A, Liu, Cailian, Holland, Aliya, Schad, Sara, Schulze, Isabell, Betof Warner, Allison, Hollmann, Travis J, Arora, Arshi, Panageas, Katherine S, Rizzuto, Gabrielle A, Duhen, Rebekka, Weinberg, Andrew D, Spencer, Christine N, Ng, David, He, Xue-Yan, Albrengues, Jean, Redmond, David, Egeblad, Mikala, Wolchok, Jedd D, Merghoub, Taha
Format:	Journal Article
Language:	English
Published:	United States 30.03.2023
Subjects:	Animals Antigenic Drift and Shift CTLA-4 Antigen Immunotherapy Melanoma Mice Neutrophils - pathology T-Lymphocytes - pathology OX40 neutrophil extracellular traps antigenic heterogeneity immunotherapy anti-tumor neutrophils CTLA-4 adoptive T cell therapies neutrophils tumor hetergeneity immune checkpoint blockade
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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