Unveiling cancer crosstalk: Mapping complexity across time and space

Cancer evolves through dynamic exchanges with its environment, harnessing these interactions to grow, adapt, and transcend the constraints that would otherwise limit its progress. A new collection of articles explores this tumor-environment crosstalk across temporal and spatial scales.

Saved in:
Bibliographic Details
Published in:PLoS biology Vol. 23; no. 7; p. e3003326
Main Author: Kang, Yibin
Format: Journal Article
Language:English
Published: United States Public Library of Science 29.07.2025
Public Library of Science (PLoS)
Subjects:
Animals
Biology and Life Sciences
Humans
Medicine and Health Sciences
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Tumor Microenvironment
ISSN:1545-7885, 1544-9173, 1545-7885
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Cancer evolves through dynamic exchanges with its environment, harnessing these interactions to grow, adapt, and transcend the constraints that would otherwise limit its progress. A new collection of articles explores this tumor-environment crosstalk across temporal and spatial scales.
AbstractList Cancer evolves through dynamic exchanges with its environment, harnessing these interactions to grow, adapt, and transcend the constraints that would otherwise limit its progress. A new collection of articles explores this tumor–environment crosstalk across temporal and spatial scales. Cancer evolves through dynamic exchanges with its environment, harnessing these interactions to grow, adapt and transcend the constraints that would otherwise limit its progress. This Editorial introduces a new collection of articles that explore this tumor–environment crosstalk across temporal and spatial scales.
Cancer evolves through dynamic exchanges with its environment, harnessing these interactions to grow, adapt, and transcend the constraints that would otherwise limit its progress. A new collection of articles explores this tumor-environment crosstalk across temporal and spatial scales.Cancer evolves through dynamic exchanges with its environment, harnessing these interactions to grow, adapt, and transcend the constraints that would otherwise limit its progress. A new collection of articles explores this tumor-environment crosstalk across temporal and spatial scales.
Cancer evolves through dynamic exchanges with its environment, harnessing these interactions to grow, adapt, and transcend the constraints that would otherwise limit its progress. A new collection of articles explores this tumor-environment crosstalk across temporal and spatial scales.
Audience Academic
Author Kang, Yibin
AuthorAffiliation 2 Ludwig Institute for Cancer Research Princeton Branch, Princeton, New Jersey, United States of America
1 Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
AuthorAffiliation_xml – name: 1 Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
– name: 2 Ludwig Institute for Cancer Research Princeton Branch, Princeton, New Jersey, United States of America
Author_xml – sequence: 1
  givenname: Yibin
  orcidid: 0000-0002-1626-6730
  surname: Kang
  fullname: Kang, Yibin
BackLink https://www.ncbi.nlm.nih.gov/pubmed/40729309$$D View this record in MEDLINE/PubMed
BookMark eNqNkttu1DAQhiNURA_wBghF4gYudvEhThxuUFVOKxVVAsqtNXYmwUtiBztbtW-P90DVSFwgW7I9881va_yfZkfOO8yy55QsKa_om7XfBAf9ctTWLzkhnLPyUXZCRSEWlZTi6MH-ODuNcU0IYzWTT7LjglSs5qQ-yd5fuxu0vXVdbsAZDLkJPsYJ-l9v8y8wjruMH8Yeb-10l8MunU92wBxck8cRDD7NHrfQR3x2WM-y648fvl98XlxefVpdnF8uTCHraUE1sKIQhJeybFmjpaFlI9O5bRiBopGIrUhBjrIhoFvSpFkJ0LQVGkvkZ9lqr9t4WKsx2AHCnfJg1S7gQ6cgTNb0qEqNWlemlrVJlyPTJdaCiXQR0zVQkbTe7bXGjR6wMeimAP1MdJ5x9qfq_I2ijJOyYmVSeHVQCP73BuOkBhsN9j049JuoOONFRaigVUJf7tEO0tusa32SNFtcnacGVJKVkidq-Q8qjQYHa9LvtzbFZwWvZwWJmfB26mATo1p9-_r_7NWPOfviYW_um_LXNgko9sDODQHbe4QStXWnOrhTbd2pDu7kfwCUo9lW
Cites_doi 10.1371/journal.pbio.3003301
10.1371/journal.pbio.3003290
10.1371/journal.pbio.3003279
10.1371/journal.pbio.3003266
10.1016/j.ccell.2023.02.016
10.1016/j.cell.2024.02.009
ContentType Journal Article
Copyright Copyright: © 2025 Yibin Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
COPYRIGHT 2025 Public Library of Science
2025 Yibin Kang 2025 Yibin Kang
Copyright_xml – notice: Copyright: © 2025 Yibin Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
– notice: COPYRIGHT 2025 Public Library of Science
– notice: 2025 Yibin Kang 2025 Yibin Kang
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
IOV
ISR
7X8
5PM
DOA
DOI 10.1371/journal.pbio.3003326
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Gale In Context: Opposing Viewpoints
Gale In Context: Science
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1545-7885
ExternalDocumentID oai_doaj_org_article_6bebb7c989cc48e2b6e9525d202b9a15
PMC12306726
A850782683
40729309
10_1371_journal_pbio_3003326
Genre Comment
Editorial
Commentary
GroupedDBID ---
123
29O
2WC
36B
53G
5VS
7X7
7XC
88E
8FE
8FH
8FI
8FJ
AAFWJ
AAUCC
AAWOE
AAYXX
ABDBF
ABIVO
ABUFD
ABUWG
ACCTH
ACGFO
ACIHN
ACPRK
ACUHS
ADBBV
AEAQA
AENEX
AEUYN
AFFHD
AFKRA
AFPKN
AFRAH
AFXKF
AHMBA
AKRSQ
ALMA_UNASSIGNED_HOLDINGS
AOIJS
ATCPS
B0M
BAIFH
BAWUL
BBNVY
BBTPI
BCNDV
BENPR
BHPHI
BPHCQ
BVXVI
BWKFM
CCPQU
CITATION
CS3
DIK
DU5
E3Z
EAD
EAP
EAS
EBD
EBS
EJD
EMB
EMK
EMOBN
EPL
ESX
F5P
FPL
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
HYE
IAG
IAO
IGS
IHR
IOV
ISE
ISN
ISR
ITC
KQ8
LK8
M1P
M48
M7P
O5R
O5S
OK1
OVT
P2P
PATMY
PHGZM
PHGZT
PIMPY
PJZUB
PPXIY
PQGLB
PQQKQ
PROAC
PSQYO
PV9
PYCSY
QF4
QN7
RNS
RPM
RZL
SJN
SV3
TR2
TUS
UKHRP
WOW
XSB
YZZ
~8M
.GJ
ADRAZ
ADXHL
C1A
CGR
CUY
CVF
ECM
EIF
IPNFZ
NPM
PUEGO
RIG
WOQ
7X8
5PM
ID FETCH-LOGICAL-c489t-1ba244503686f2db8c16d8503fd20a4d8eef58c13e8d0abf0df0d75ab1f5be6e3
IEDL.DBID DOA
ISICitedReferencesCount 0
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001539757800005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1545-7885
1544-9173
IngestDate Tue Oct 14 19:04:54 EDT 2025
Tue Nov 04 02:04:47 EST 2025
Sat Nov 01 15:05:31 EDT 2025
Tue Nov 11 10:45:27 EST 2025
Tue Nov 04 18:12:47 EST 2025
Thu Nov 13 15:56:14 EST 2025
Thu Nov 13 15:56:11 EST 2025
Thu Aug 28 04:45:17 EDT 2025
Sat Nov 29 07:42:36 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 7
Language English
License Copyright: © 2025 Yibin Kang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c489t-1ba244503686f2db8c16d8503fd20a4d8eef58c13e8d0abf0df0d75ab1f5be6e3
Notes SourceType-Scholarly Journals-1
content type line 23
ObjectType-Editorial-2
ObjectType-Commentary-1
The authors have declared that no competing interests exist.
ORCID 0000-0002-1626-6730
OpenAccessLink https://doaj.org/article/6bebb7c989cc48e2b6e9525d202b9a15
PMID 40729309
PQID 3234701517
PQPubID 23479
ParticipantIDs doaj_primary_oai_doaj_org_article_6bebb7c989cc48e2b6e9525d202b9a15
pubmedcentral_primary_oai_pubmedcentral_nih_gov_12306726
proquest_miscellaneous_3234701517
gale_infotracmisc_A850782683
gale_infotracacademiconefile_A850782683
gale_incontextgauss_ISR_A850782683
gale_incontextgauss_IOV_A850782683
pubmed_primary_40729309
crossref_primary_10_1371_journal_pbio_3003326
PublicationCentury 2000
PublicationDate 20250729
PublicationDateYYYYMMDD 2025-07-29
PublicationDate_xml – month: 7
  year: 2025
  text: 20250729
  day: 29
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: San Francisco, CA USA
PublicationTitle PLoS biology
PublicationTitleAlternate PLoS Biol
PublicationYear 2025
Publisher Public Library of Science
Public Library of Science (PLoS)
Publisher_xml – name: Public Library of Science
– name: Public Library of Science (PLoS)
References L Laplane (pbio.3003326.ref003) 2025; 23
KE de Visser (pbio.3003326.ref001) 2023; 41
F Liu (pbio.3003326.ref005) 2025; 23
Y Qiu (pbio.3003326.ref009) 2025; 23
LL Munn (pbio.3003326.ref004) 2025; 23
JT Huang (pbio.3003326.ref006) 2025; 23
J Mo (pbio.3003326.ref008) 2025; 23
C Swanton (pbio.3003326.ref002) 2024; 187
SR Rosenbaum (pbio.3003326.ref010) 2025; 23
EK Sloan (pbio.3003326.ref007) 2025; 23
40705711 - PLoS Biol. 2025 Jul 24;23(7):e3003276. doi: 10.1371/journal.pbio.3003276.
40658684 - PLoS Biol. 2025 Jul 14;23(7):e3003284. doi: 10.1371/journal.pbio.3003284.
40680084 - PLoS Biol. 2025 Jul 18;23(7):e3003290. doi: 10.1371/journal.pbio.3003290.
40690420 - PLoS Biol. 2025 Jul 21;23(7):e3003266. doi: 10.1371/journal.pbio.3003266.
40700394 - PLoS Biol. 2025 Jul 23;23(7):e3003269. doi: 10.1371/journal.pbio.3003269.
40720365 - PLoS Biol. 2025 Jul 28;23(7):e3003279. doi: 10.1371/journal.pbio.3003279.
40658744 - PLoS Biol. 2025 Jul 14;23(7):e3003299. doi: 10.1371/journal.pbio.3003299.
40663561 - PLoS Biol. 2025 Jul 15;23(7):e3003301. doi: 10.1371/journal.pbio.3003301.
References_xml – volume: 23
  issue: 7
  year: 2025
  ident: pbio.3003326.ref010
  article-title: Masters of adaptation: how cancer and immune cell plasticity mediates tumor progression
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.3003301
– volume: 23
  issue: 7
  year: 2025
  ident: pbio.3003326.ref008
  article-title: TiME for a change: the tumor microenvironment as the missing piece in cancer therapeutics
  publication-title: PLoS Biol
– volume: 23
  issue: 7
  year: 2025
  ident: pbio.3003326.ref003
  article-title: Applying multilevel selection to understand cancer evolution and progression
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.3003290
– volume: 23
  issue: 7
  year: 2025
  ident: pbio.3003326.ref009
  article-title: Bi-directional metabolic reprogramming between cancer cells and T cells reshapes the anti-tumor immune response
  publication-title: PLoS Biol
– volume: 23
  issue: 7
  year: 2025
  ident: pbio.3003326.ref006
  article-title: Omics datasets can bridge the gap between tumor biology and patient care
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.3003279
– volume: 23
  issue: 7
  year: 2025
  ident: pbio.3003326.ref007
  article-title: Can the tumor neural niche be targeted to re-program cancer?
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.3003266
– volume: 23
  issue: 7
  year: 2025
  ident: pbio.3003326.ref004
  article-title: Challenges and opportunities for the next generation of computational tumor models
  publication-title: PLoS Biol
– volume: 23
  issue: 7
  year: 2025
  ident: pbio.3003326.ref005
  article-title: Decoding metastatic microenvironments through single-cell omics reveals new insights into niche dynamics and tumor evolution
  publication-title: PLoS Biol
– volume: 41
  start-page: 374
  issue: 3
  year: 2023
  ident: pbio.3003326.ref001
  article-title: The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2023.02.016
– volume: 187
  start-page: 1589
  issue: 7
  year: 2024
  ident: pbio.3003326.ref002
  article-title: Embracing cancer complexity: hallmarks of systemic disease
  publication-title: Cell
  doi: 10.1016/j.cell.2024.02.009
– reference: 40705711 - PLoS Biol. 2025 Jul 24;23(7):e3003276. doi: 10.1371/journal.pbio.3003276.
– reference: 40658684 - PLoS Biol. 2025 Jul 14;23(7):e3003284. doi: 10.1371/journal.pbio.3003284.
– reference: 40680084 - PLoS Biol. 2025 Jul 18;23(7):e3003290. doi: 10.1371/journal.pbio.3003290.
– reference: 40658744 - PLoS Biol. 2025 Jul 14;23(7):e3003299. doi: 10.1371/journal.pbio.3003299.
– reference: 40690420 - PLoS Biol. 2025 Jul 21;23(7):e3003266. doi: 10.1371/journal.pbio.3003266.
– reference: 40663561 - PLoS Biol. 2025 Jul 15;23(7):e3003301. doi: 10.1371/journal.pbio.3003301.
– reference: 40700394 - PLoS Biol. 2025 Jul 23;23(7):e3003269. doi: 10.1371/journal.pbio.3003269.
– reference: 40720365 - PLoS Biol. 2025 Jul 28;23(7):e3003279. doi: 10.1371/journal.pbio.3003279.
SSID ssj0022928
Score 2.4826736
Snippet Cancer evolves through dynamic exchanges with its environment, harnessing these interactions to grow, adapt, and transcend the constraints that would otherwise...
SourceID doaj
pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage e3003326
SubjectTerms Animals
Biology and Life Sciences
Humans
Medicine and Health Sciences
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Tumor Microenvironment
Title Unveiling cancer crosstalk: Mapping complexity across time and space
URI https://www.ncbi.nlm.nih.gov/pubmed/40729309
https://www.proquest.com/docview/3234701517
https://pubmed.ncbi.nlm.nih.gov/PMC12306726
https://doaj.org/article/6bebb7c989cc48e2b6e9525d202b9a15
Volume 23
WOSCitedRecordID wos001539757800005&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 1545-7885
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0022928
  issn: 1545-7885
  databaseCode: DOA
  dateStart: 20030101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 1545-7885
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0022928
  issn: 1545-7885
  databaseCode: M7P
  dateStart: 20031001
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Environmental Science Database
  customDbUrl:
  eissn: 1545-7885
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0022928
  issn: 1545-7885
  databaseCode: PATMY
  dateStart: 20031001
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/environmentalscience
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1545-7885
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0022928
  issn: 1545-7885
  databaseCode: 7X7
  dateStart: 20031001
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1545-7885
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0022928
  issn: 1545-7885
  databaseCode: BENPR
  dateStart: 20031001
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Publicly Available Content Database
  customDbUrl:
  eissn: 1545-7885
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0022928
  issn: 1545-7885
  databaseCode: PIMPY
  dateStart: 20031001
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
– providerCode: PRVATS
  databaseName: Public Library of Science (PLoS) Journals Open Access
  customDbUrl:
  eissn: 1545-7885
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0022928
  issn: 1545-7885
  databaseCode: FPL
  dateStart: 20030101
  isFulltext: true
  titleUrlDefault: http://www.plos.org/publications/
  providerName: Public Library of Science
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3daxQxEA9aFXyR-tnVeqwi-LTtbbKbj7612sNCey7VlvMpJNnEHsJeuY-i_70z2b1yi4gvwhG4nYElv0kyM-zkN4S8q5kzghU-49zYrDCMZ0paAUORm1KY4CLjzeWpGI_lZKKqjVZfWBPW0gO3wO1z660VTknlXCE9tdyrkpY1JO1WmXi9nELUs06mulSLqthVFalmYDsL1l2aYyLf72y0d22nsz2GvcyQWGHDKUXu_j9P6A0X1S-f3PBHo23yqAsk08N2Ao_JHd88IQ_a1pK_npKPF82Nn-Jd89ShYedpfDWE2j8O0jODrAwgwXpy_xMC8dREcYqt5lPT1CkcNM4_Ixej468fPmVdx4QMsFHLLLcG3HUJXknyQGsrXc5rCf8D4GWKWnofSnjIvKyHxoZhDT9RGpuH0nru2XOy1cwav0PSEArH89rCJmeQFQVr4TDgVklTBM8NTUi2hkxft8QYOn4dE5BQtBBohFh3ECfkCHG91UVa6_gAjK07Y-t_GTshb9EqGokrGqyM-W5Wi4U--XypD2GaEO1wyf6m9OW8p_S-UwozMKIz3W0EmDwSYvU0d3uasP1cT_xmvUI0irBmrfGz1UIzygoB0VYuEvKiXTG3s0daOsWGKiGyt5Z68PQlzfQqsn_nmDQKyl_-D0BfkYcUGxoPRUbVLtlazlf-NbnvbpbTxXxA7oqJiKMckHtHx-PqfBD3GYyj6nSAhbIVSKqTs-rbb5MhLog
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Unveiling+cancer+crosstalk%3A+Mapping+complexity+across+time+and+space&rft.jtitle=PLoS+biology&rft.au=Kang%2C+Yibin&rft.date=2025-07-29&rft.pub=Public+Library+of+Science&rft.issn=1544-9173&rft.volume=23&rft.issue=7&rft_id=info:doi/10.1371%2Fjournal.pbio.3003326&rft.externalDocID=A850782683
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1545-7885&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1545-7885&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1545-7885&client=summon