Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma

The intratumor microenvironment generates phenotypically distinct but interconvertible malignant cell subpopulations that fuel metastatic spread and therapeutic resistance. Whether different microenvironmental cues impose invasive or therapy-resistant phenotypes via a common mechanism is unknown. In...

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Bibliographic Details
Published in:	Genes & development Vol. 31; no. 1; p. 18
Main Authors:	Falletta, Paola, Sanchez-Del-Campo, Luis, Chauhan, Jagat, Effern, Maike, Kenyon, Amy, Kershaw, Christopher J, Siddaway, Robert, Lisle, Richard, Freter, Rasmus, Daniels, Matthew J, Lu, Xin, Tüting, Thomas, Middleton, Mark, Buffa, Francesca M, Willis, Anne E, Pavitt, Graham, Ronai, Ze'ev A, Sauka-Spengler, Tatjana, Hölzel, Michael, Goding, Colin R
Format:	Journal Article
Language:	English
Published:	United States 01.01.2017
Subjects:	Animals Cell Plasticity - genetics Cellular Microenvironment Cellular Reprogramming - genetics Drug Resistance, Neoplasm - genetics Evolution, Molecular Feedback, Physiological Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Glutamine - pharmacology Humans Immunotherapy Melanoma - drug therapy Melanoma - genetics Melanoma - metabolism Microphthalmia-Associated Transcription Factor - genetics Neoplasm Invasiveness - genetics Neural Crest - cytology Phenotype Protein Biosynthesis - genetics Transcription Factors - metabolism Zebrafish - embryology invasiveness melanoma TNFα MITF phenotype-switching
ISSN:	1549-5477, 1549-5477
Online Access:	Get more information
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