Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense

IQ domain GTPase-activating protein 1 (IQGAP1) contributes to cytoskeletal network regulation in epithelial cells by its scaffolding properties and by binding the Rho GTPase Rac1 to maintain its activity. The functions of IQGAP1 in endothelial cells beyond angiogenesis remain unclear. We hypothesize...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology Jg. 31; H. 11; S. 2643
Hauptverfasser:	David, Sascha, Ghosh, Chandra C, Mukherjee, Aditi, Parikh, Samir M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.11.2011
Schlagworte:	Adherens Junctions - physiology Angiopoietin-1 - metabolism Cell Membrane Permeability - physiology Cells, Cultured Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Gap Junctions - physiology Humans rac1 GTP-Binding Protein - metabolism ras GTPase-Activating Proteins - antagonists & inhibitors ras GTPase-Activating Proteins - drug effects ras GTPase-Activating Proteins - metabolism RNA, Small Interfering - pharmacology Signal Transduction - physiology
ISSN:	1524-4636, 1524-4636
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