Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense

IQ domain GTPase-activating protein 1 (IQGAP1) contributes to cytoskeletal network regulation in epithelial cells by its scaffolding properties and by binding the Rho GTPase Rac1 to maintain its activity. The functions of IQGAP1 in endothelial cells beyond angiogenesis remain unclear. We hypothesize...

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Bibliographic Details

Published in:	Arteriosclerosis, thrombosis, and vascular biology Vol. 31; no. 11; p. 2643
Main Authors:	David, Sascha, Ghosh, Chandra C, Mukherjee, Aditi, Parikh, Samir M
Format:	Journal Article
Language:	English
Published:	United States 01.11.2011
Subjects:	Adherens Junctions - physiology Angiopoietin-1 - metabolism Cell Membrane Permeability - physiology Cells, Cultured Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Gap Junctions - physiology Humans rac1 GTP-Binding Protein - metabolism ras GTPase-Activating Proteins - antagonists & inhibitors ras GTPase-Activating Proteins - drug effects ras GTPase-Activating Proteins - metabolism RNA, Small Interfering - pharmacology Signal Transduction - physiology
ISSN:	1524-4636, 1524-4636
Online Access:	Get more information
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