Subcortical (thalamic) automated seizure detection: A new option for contingent therapy delivery

Summary The feasibility of automated detection of cortical‐onset epileptic seizures from subcortical structures such as the thalamus was investigated via simultaneous recording of electroencephalography (EEG) and anterior and centromedian thalamic nuclei electrical signals (electrothalamography) in...

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Bibliographic Details
Published in:Epilepsia (Copenhagen) Vol. 56; no. 10; pp. e156 - e160
Main Authors: Osorio, Ivan, Frei, Mark G., Lozano, Andres M., Wennberg, Richard
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01.10.2015
Subjects:
Adult
Automation
Computerized electrical current delivery
Computerized seizure detection
Convulsions & seizures
Diagnosis, Computer-Assisted
EEG
Electroencephalography
Electrothalamography
Epilepsy
Female
Humans
Male
Retrospective Studies
Seizures - diagnosis
Seizures - therapy
Subcortical
Thalamus - pathology
Thalamus - physiology
Young Adult
Computerized electrical current delivery
Electrothalamography
EEG
Subcortical
Computerized seizure detection
ISSN:0013-9580, 1528-1167, 1528-1167
Online Access:Get full text
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Summary:Summary The feasibility of automated detection of cortical‐onset epileptic seizures from subcortical structures such as the thalamus was investigated via simultaneous recording of electroencephalography (EEG) and anterior and centromedian thalamic nuclei electrical signals (electrothalamography) in nine subjects with pharmacoresistant seizures admitted to an epilepsy monitoring unit after deep brain stimulating electrode implantation. Thalamic electrical signals were analyzed using a validated seizure detection algorithm, and times of seizure onset and termination were compared to those determined through visual analysis of video‐EEG. Ictal activity was recorded from the scalp and thalamic nuclei in three subjects who had seizures during the 3–4‐day recording period. In the majority of seizures, ictal activity in the thalamic nuclei preceded electrographic onset as determined from the EEG or clinical onset as determined from behavioral observations. Interictal epileptiform discharges were also recorded from the thalamus and in certain instances had no scalp representation. Subcortical/thalamic detection of cortical‐onset seizures is feasible. This approach would enable contingent therapy delivery and may be particularly valuable for subjects with multiple or difficult‐to‐localize epileptogenic regions.
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ISSN:0013-9580
1528-1167
1528-1167
DOI:10.1111/epi.13124