Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis

We molecularly dissected leptomeningeal metastasis, or spread of cancer to the cerebrospinal fluid (CSF), which is a frequent and fatal condition mediated by unknown mechanisms. We selected lung and breast cancer cell lines for the ability to infiltrate and grow in CSF, a remarkably acellular, mitog...

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Bibliographic Details
Published in:	Cell Vol. 168; no. 6; pp. 1101 - 1113.e13
Main Authors:	Boire, Adrienne, Zou, Yilong, Shieh, Jason, Macalinao, Danilo G, Pentsova, Elena, Massagué, Joan
Format:	Journal Article
Language:	English
Published:	United States 09.03.2017
Subjects:	Animals Breast Neoplasms - pathology Cerebrospinal Fluid Choroid Plexus - blood supply Complement C3 - genetics Complement C3 - metabolism Humans Intercellular Signaling Peptides and Proteins - metabolism Lung Neoplasms - pathology Macrophage-1 Antigen - metabolism Meningeal Neoplasms - secondary Mice Neoplasm Metastasis - pathology Signal Transduction Tumor Microenvironment Up-Regulation amphiregulin lung cancer leptomeningeal metastasis GDNF carcinomatous meningitis PDGF cerebrospinal fluid breast cancer complement C3 brain metastasis choroid plexus
ISSN:	1097-4172
Online Access:	Get more information
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