Reducing acetylated tau is neuroprotective in brain injury

Traumatic brain injury (TBI) is the largest non-genetic, non-aging related risk factor for Alzheimer's disease (AD). We report here that TBI induces tau acetylation (ac-tau) at sites acetylated also in human AD brain. This is mediated by S-nitrosylated-GAPDH, which simultaneously inactivates Si...

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Veröffentlicht in:	Cell Jg. 184; H. 10; S. 2715
Hauptverfasser:	Shin, Min-Kyoo, Vázquez-Rosa, Edwin, Koh, Yeojung, Dhar, Matasha, Chaubey, Kalyani, Cintrón-Pérez, Coral J, Barker, Sarah, Miller, Emiko, Franke, Kathryn, Noterman, Maria F, Seth, Divya, Allen, Rachael S, Motz, Cara T, Rao, Sriganesh Ramachandra, Skelton, Lara A, Pardue, Machelle T, Fliesler, Steven J, Wang, Chao, Tracy, Tara E, Gan, Li, Liebl, Daniel J, Savarraj, Jude P J, Torres, Glenda L, Ahnstedt, Hilda, McCullough, Louise D, Kitagawa, Ryan S, Choi, H Alex, Zhang, Pengyue, Hou, Yuan, Chiang, Chien-Wei, Li, Lang, Ortiz, Francisco, Kilgore, Jessica A, Williams, Noelle S, Whitehair, Victoria C, Gefen, Tamar, Flanagan, Margaret E, Stamler, Jonathan S, Jain, Mukesh K, Kraus, Allison, Cheng, Feixiong, Reynolds, James D, Pieper, Andrew A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 13.05.2021
Schlagworte:	Acetylation Alzheimer Disease - etiology Alzheimer Disease - metabolism Alzheimer Disease - prevention & control Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biomarkers - blood Biomarkers - metabolism Brain Injuries, Traumatic - complications Brain Injuries, Traumatic - metabolism Cell Line Diflunisal - therapeutic use Female Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) Humans Male Mice Mice, Inbred C57BL Neurons - metabolism Neuroprotection p300-CBP Transcription Factors - antagonists & inhibitors p300-CBP Transcription Factors - metabolism Salicylates - therapeutic use Sirtuin 1 - metabolism tau Proteins - blood tau Proteins - metabolism acetylation congenital muscular dystrophy omigapil P7C3 Alzheimer’s disease salsalate neuroprotection diflunisal neurodegeneration traumatic brain injury tau
ISSN:	1097-4172, 1097-4172
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