Sclerostin's role in bone–muscle crosstalk and osteoporosis pathogenesis

This review examines sclerostin, a critical regulator of Wnt signaling, focusing on its role in bone homeostasis and its emerging involvement in muscle–bone crosstalk. It examines the regulatory influence of hormones, mechanical stress, and myokines on sclerostin expression under both physiological...

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Vydané v:Osteoporosis and Sarcopenia Ročník 11; číslo 3; s. 69 - 82
Hlavní autori: Shahid, Hamzah, Morya, Vivek Kumar, Noh, Kyu-Cheol
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Netherlands Elsevier B.V 01.09.2025
Elsevier
대한골다공증학회
Predmet:
Crosstalk
Endocrinology and Metabolism
Molecular interaction
Myokines
Osteoporosis
Regulators
Sclerostin
정형외과학
Myokines
Osteoporosis
Sclerostin
Molecular interaction
Regulators
Crosstalk
ISSN:2405-5255, 2405-5263, 2405-5263
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Abstract This review examines sclerostin, a critical regulator of Wnt signaling, focusing on its role in bone homeostasis and its emerging involvement in muscle–bone crosstalk. It examines the regulatory influence of hormones, mechanical stress, and myokines on sclerostin expression under both physiological and pathological conditions. Recent advances underscore sclerostin's role in osteoporosis pathogenesis and its involvement in bone remodeling, while also revealing its emerging significance in muscle–bone communication. Despite these insights, the underlying mechanisms of its regulation remain incompletely understood. By consolidating recent research, this review provides a comprehensive perspective on sclerostin's multifaceted roles and their implications for bone and muscle health.
AbstractList This review examines sclerostin, a critical regulator of Wnt signaling, focusing on its role in bone homeostasis and its emerging involvement in muscle–bone crosstalk. It examines the regulatory influence of hormones, mechanical stress, and myokines on sclerostin expression under both physiological and pathological conditions. Recent advances underscore sclerostin's role in osteoporosis pathogenesis and its involvement in bone remodeling, while also revealing its emerging significance in muscle–bone communication. Despite these insights, the underlying mechanisms of its regulation remain incompletely understood. By consolidating recent research, this review provides a comprehensive perspective on sclerostin's multifaceted roles and their implications for bone and muscle health.
AbstractThis review examines sclerostin, a critical regulator of Wnt signaling, focusing on its role in bone homeostasis and its emerging involvement in muscle–bone crosstalk. It examines the regulatory influence of hormones, mechanical stress, and myokines on sclerostin expression under both physiological and pathological conditions. Recent advances underscore sclerostin's role in osteoporosis pathogenesis and its involvement in bone remodeling, while also revealing its emerging significance in muscle–bone communication. Despite these insights, the underlying mechanisms of its regulation remain incompletely understood. By consolidating recent research, this review provides a comprehensive perspective on sclerostin's multifaceted roles and their implications for bone and muscle health.
This review examines sclerostin, a critical regulator of Wnt signaling, focusing on its role in bone homeostasis and its emerging involvement in muscle–bone crosstalk. It examines the regulatory influence of hormones, mechanical stress, and myokines on sclerostin expression under both physiological and pathological conditions. Recent advances underscore sclerostin’s role in osteoporosis pathogenesis and its involvement in bone remodeling, while also revealing its emerging significance in muscle–bone communication. Despite these insights, the underlying mechanisms of its regulation remain incompletely understood. By consolidating recent research, this review provides a comprehensive perspective on sclerostin’s multifaceted roles and their implications for bone and muscle health. KCI Citation Count: 0
This review examines sclerostin, a critical regulator of Wnt signaling, focusing on its role in bone homeostasis and its emerging involvement in muscle-bone crosstalk. It examines the regulatory influence of hormones, mechanical stress, and myokines on sclerostin expression under both physiological and pathological conditions. Recent advances underscore sclerostin's role in osteoporosis pathogenesis and its involvement in bone remodeling, while also revealing its emerging significance in muscle-bone communication. Despite these insights, the underlying mechanisms of its regulation remain incompletely understood. By consolidating recent research, this review provides a comprehensive perspective on sclerostin's multifaceted roles and their implications for bone and muscle health.This review examines sclerostin, a critical regulator of Wnt signaling, focusing on its role in bone homeostasis and its emerging involvement in muscle-bone crosstalk. It examines the regulatory influence of hormones, mechanical stress, and myokines on sclerostin expression under both physiological and pathological conditions. Recent advances underscore sclerostin's role in osteoporosis pathogenesis and its involvement in bone remodeling, while also revealing its emerging significance in muscle-bone communication. Despite these insights, the underlying mechanisms of its regulation remain incompletely understood. By consolidating recent research, this review provides a comprehensive perspective on sclerostin's multifaceted roles and their implications for bone and muscle health.
Author Shahid, Hamzah
Morya, Vivek Kumar
Noh, Kyu-Cheol
Author_xml – sequence: 1
  givenname: Hamzah
  surname: Shahid
  fullname: Shahid, Hamzah
  organization: School of Medicine, Hallym University, Chuncheon, South Korea
– sequence: 2
  givenname: Vivek Kumar
  orcidid: 0000-0002-5901-4883
  surname: Morya
  fullname: Morya, Vivek Kumar
  email: moryavivek@hallym.ac.kr
  organization: School of Medicine, Hallym University, Chuncheon, South Korea
– sequence: 3
  givenname: Kyu-Cheol
  orcidid: 0000-0001-8738-2977
  surname: Noh
  fullname: Noh, Kyu-Cheol
  email: happynoh@gmail.com
  organization: School of Medicine, Hallym University, Chuncheon, South Korea
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Keywords Myokines
Osteoporosis
Sclerostin
Molecular interaction
Regulators
Crosstalk
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Snippet This review examines sclerostin, a critical regulator of Wnt signaling, focusing on its role in bone homeostasis and its emerging involvement in muscle–bone...
AbstractThis review examines sclerostin, a critical regulator of Wnt signaling, focusing on its role in bone homeostasis and its emerging involvement in...
This review examines sclerostin, a critical regulator of Wnt signaling, focusing on its role in bone homeostasis and its emerging involvement in muscle-bone...
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SubjectTerms Crosstalk
Endocrinology and Metabolism
Molecular interaction
Myokines
Osteoporosis
Regulators
Sclerostin
정형외과학
Title Sclerostin's role in bone–muscle crosstalk and osteoporosis pathogenesis
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