TCS: A New Multiple Sequence Alignment Reliability Measure to Estimate Alignment Accuracy and Improve Phylogenetic Tree Reconstruction

Multiple sequence alignment (MSA) is a key modeling procedure when analyzing biological sequences. Homology and evolutionary modeling are the most common applications of MSAs. Both are known to be sensitive to the underlying MSA accuracy. In this work, we show how this problem can be partly overcome...

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Bibliographic Details
Published in:	Molecular biology and evolution Vol. 31; no. 6; pp. 1625 - 1637
Main Authors:	Chang, Jia-Ming, Di Tommaso, Paolo, Notredame, Cedric
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press 01.06.2014 Oxford University Press (OUP)
Subjects:	Accuracy Alignment Bioinformatics Coffee Computer Science Datasets Homology Life Sciences Modelling Models, Molecular Molecular biology Nucleotide sequence Phylogenetics Phylogeny Quantitative Methods Reconstruction Reproducibility of Results Sequence Alignment - methods Sequence Homology Simulation Software Yeast Yeasts phylogeny homology modeling alignment confidence alignment uncertainty T-Coffee multiple sequence alignment
ISSN:	0737-4038, 1537-1719, 1537-1719
Online Access:	Get full text
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