Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals

Vaccine-mediated immunity often relies on the generation of protective antibodies and memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth comparison of the GC responses elicited by SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals has not yet been...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cell Jg. 185; H. 6; S. 1008
Hauptverfasser: Lederer, Katlyn, Bettini, Emily, Parvathaneni, Kalpana, Painter, Mark M, Agarwal, Divyansh, Lundgreen, Kendall A, Weirick, Madison, Muralidharan, Kavitha, Castaño, Diana, Goel, Rishi R, Xu, Xiaoming, Drapeau, Elizabeth M, Gouma, Sigrid, Ort, Jordan T, Awofolaju, Moses, Greenplate, Allison R, Le Coz, Carole, Romberg, Neil, Trofe-Clark, Jennifer, Malat, Gregory, Jones, Lisa, Rosen, Mark, Weiskopf, Daniela, Sette, Alessandro, Besharatian, Behdad, Kaminiski, Mary, Hensley, Scott E, Bates, Paul, Wherry, E John, Naji, Ali, Bhoj, Vijay, Locci, Michela
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 17.03.2022
Schlagworte:
SARS-CoV-2
kidney transplant recipients
germinal centers
mRNA vaccines
neutralizing antibodies
fine-needle aspiration
immunocompromised
memory B cells
T follicular helper cells
germinal center B cells
ISSN:1097-4172, 1097-4172
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Vaccine-mediated immunity often relies on the generation of protective antibodies and memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth comparison of the GC responses elicited by SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals has not yet been performed due to the challenge of directly probing human lymph nodes. Herein, through a fine-needle aspiration-based approach, we profiled the immune responses to SARS-CoV-2 mRNA vaccines in lymph nodes of healthy individuals and kidney transplant recipients (KTXs). We found that, unlike healthy subjects, KTXs presented deeply blunted SARS-CoV-2-specific GC B cell responses coupled with severely hindered T follicular helper cell, SARS-CoV-2 receptor binding domain-specific memory B cell, and neutralizing antibody responses. KTXs also displayed reduced SARS-CoV-2-specific CD4 and CD8 T cell frequencies. Broadly, these data indicate impaired GC-derived immunity in immunocompromised individuals and suggest a GC origin for certain humoral and memory B cell responses following mRNA vaccination.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2022.01.027