Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals

Vaccine-mediated immunity often relies on the generation of protective antibodies and memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth comparison of the GC responses elicited by SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals has not yet been...

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Podrobná bibliografia
Vydané v:	Cell Ročník 185; číslo 6; s. 1008
Hlavní autori:	Lederer, Katlyn, Bettini, Emily, Parvathaneni, Kalpana, Painter, Mark M, Agarwal, Divyansh, Lundgreen, Kendall A, Weirick, Madison, Muralidharan, Kavitha, Castaño, Diana, Goel, Rishi R, Xu, Xiaoming, Drapeau, Elizabeth M, Gouma, Sigrid, Ort, Jordan T, Awofolaju, Moses, Greenplate, Allison R, Le Coz, Carole, Romberg, Neil, Trofe-Clark, Jennifer, Malat, Gregory, Jones, Lisa, Rosen, Mark, Weiskopf, Daniela, Sette, Alessandro, Besharatian, Behdad, Kaminiski, Mary, Hensley, Scott E, Bates, Paul, Wherry, E John, Naji, Ali, Bhoj, Vijay, Locci, Michela
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 17.03.2022
Predmet:	SARS-CoV-2 kidney transplant recipients germinal centers mRNA vaccines neutralizing antibodies fine-needle aspiration immunocompromised memory B cells T follicular helper cells germinal center B cells
ISSN:	1097-4172, 1097-4172
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Popis
Shrnutí:	Vaccine-mediated immunity often relies on the generation of protective antibodies and memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth comparison of the GC responses elicited by SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals has not yet been performed due to the challenge of directly probing human lymph nodes. Herein, through a fine-needle aspiration-based approach, we profiled the immune responses to SARS-CoV-2 mRNA vaccines in lymph nodes of healthy individuals and kidney transplant recipients (KTXs). We found that, unlike healthy subjects, KTXs presented deeply blunted SARS-CoV-2-specific GC B cell responses coupled with severely hindered T follicular helper cell, SARS-CoV-2 receptor binding domain-specific memory B cell, and neutralizing antibody responses. KTXs also displayed reduced SARS-CoV-2-specific CD4 and CD8 T cell frequencies. Broadly, these data indicate impaired GC-derived immunity in immunocompromised individuals and suggest a GC origin for certain humoral and memory B cell responses following mRNA vaccination.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1097-4172 1097-4172
DOI:	10.1016/j.cell.2022.01.027