An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint

At the species level, immunity depends on the selection and transmission of protective components of the immune system. A microbe-induced population of RORγ-expressing regulatory T cells (Tregs) is essential in controlling gut inflammation. We uncovered a non-genetic, non-epigenetic, non-microbial m...

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Bibliographic Details
Published in:	Cell Vol. 181; no. 6; p. 1276
Main Authors:	Ramanan, Deepshika, Sefik, Esen, Galván-Peña, Silvia, Wu, Meng, Yang, Liang, Yang, Zhen, Kostic, Aleksandar, Golovkina, Tatyana V, Kasper, Dennis L, Mathis, Diane, Benoist, Christophe
Format:	Journal Article
Language:	English
Published:	United States 11.06.2020
Subjects:	Animals Digestive System - immunology Disease Susceptibility - immunology Female Gastrointestinal Microbiome - immunology Homeostasis - immunology Immunoglobulin A - immunology Inflammation - immunology Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Mice, Inbred NOD Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology T-Lymphocytes, Regulatory - immunology Rorγ entero-mammary axis IgA maternal transmission colonic Tregs Tregs
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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