In Vivo Cellular Reprogramming: The Next Generation

Cellular reprogramming technology has created new opportunities in understanding human disease, drug discovery, and regenerative medicine. While a combinatorial code was initially found to reprogram somatic cells to pluripotency, a "second generation" of cellular reprogramming involves lin...

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Bibliographic Details
Published in:Cell Vol. 166; no. 6; p. 1386
Main Authors: Srivastava, Deepak, DeWitt, Natalie
Format: Journal Article
Language:English
Published: United States 08.09.2016
Subjects:
Cellular Reprogramming
Humans
Induced Pluripotent Stem Cells - cytology
Insulin-Secreting Cells - cytology
Myocytes, Cardiac - cytology
Neurons - cytology
Regenerative Medicine - trends
Research - trends
Translational Medical Research - standards
Translational Medical Research - trends
ISSN:1097-4172, 1097-4172
Online Access:Get more information
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Summary:Cellular reprogramming technology has created new opportunities in understanding human disease, drug discovery, and regenerative medicine. While a combinatorial code was initially found to reprogram somatic cells to pluripotency, a "second generation" of cellular reprogramming involves lineage-restricted transcription factors and microRNAs that directly reprogram one somatic cell to another. This technology was enabled by gene networks active during development, which induce global shifts in the epigenetic landscape driving cell fate decisions. A major utility of direct reprogramming is the potential of harnessing resident support cells within damaged organs to regenerate lost tissue by converting them into the desired cell type in situ. Here, we review the progress in direct cellular reprogramming, with a focus on the paradigm of in vivo reprogramming for regenerative medicine, while pointing to hurdles that must be overcome to translate this technology into future therapeutics.
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ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2016.08.055