Molecular topography of an entire nervous system

We have produced gene expression profiles of all 302 neurons of the C. elegans nervous system that match the single-cell resolution of its anatomy and wiring diagram. Our results suggest that individual neuron classes can be solely identified by combinatorial expression of specific gene families. Fo...

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Vydáno v:Cell Ročník 184; číslo 16; s. 4329
Hlavní autoři: Taylor, Seth R, Santpere, Gabriel, Weinreb, Alexis, Barrett, Alec, Reilly, Molly B, Xu, Chuan, Varol, Erdem, Oikonomou, Panos, Glenwinkel, Lori, McWhirter, Rebecca, Poff, Abigail, Basavaraju, Manasa, Rafi, Ibnul, Yemini, Eviatar, Cook, Steven J, Abrams, Alexander, Vidal, Berta, Cros, Cyril, Tavazoie, Saeed, Sestan, Nenad, Hammarlund, Marc, Hobert, Oliver, Miller, 3rd, David M
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 05.08.2021
Témata:
Animals
Caenorhabditis elegans - genetics
Caenorhabditis elegans - metabolism
Caenorhabditis elegans Proteins - genetics
Caenorhabditis elegans Proteins - metabolism
Fluorescent Dyes - metabolism
Gene Expression Regulation, Developmental
Genes, Reporter
Larva - metabolism
Nervous System - metabolism
Neurons - metabolism
Neuropeptides - genetics
Neuropeptides - metabolism
Nucleotide Motifs - genetics
Regulatory Sequences, Nucleic Acid - genetics
RNA-Seq
Signal Transduction - genetics
Transcription Factors - metabolism
Transcription, Genetic
C. elegans
cell adhesion molecules
RNA-seq
neuron
single-cell
connectome
neuropeptides
gene regulatory motifs
ISSN:1097-4172, 1097-4172
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Popis
Shrnutí:We have produced gene expression profiles of all 302 neurons of the C. elegans nervous system that match the single-cell resolution of its anatomy and wiring diagram. Our results suggest that individual neuron classes can be solely identified by combinatorial expression of specific gene families. For example, each neuron class expresses distinct codes of ∼23 neuropeptide genes and ∼36 neuropeptide receptors, delineating a complex and expansive "wireless" signaling network. To demonstrate the utility of this comprehensive gene expression catalog, we used computational approaches to (1) identify cis-regulatory elements for neuron-specific gene expression and (2) reveal adhesion proteins with potential roles in process placement and synaptic specificity. Our expression data are available at https://cengen.org and can be interrogated at the web application CengenApp. We expect that this neuron-specific directory of gene expression will spur investigations of underlying mechanisms that define anatomy, connectivity, and function throughout the C. elegans nervous system.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2021.06.023