Presymptomatic spinal cord pathology in c9orf72 mutation carriers: A longitudinal neuroimaging study

Objective C9orf72 hexanucleotide repeats expansions account for almost half of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) cases. Recent imaging studies in asymptomatic C9orf72 carriers have demonstrated cerebral white (WM) and gray matter (GM) degeneration before...

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Bibliographic Details
Published in:	Annals of neurology Vol. 86; no. 2; pp. 158 - 167
Main Authors:	Querin, Giorgia, Bede, Peter, El Mendili, Mohamed Mounir, Li, Menghan, Pélégrini‐Issac, Mélanie, Rinaldi, Daisy, Catala, Martin, Saracino, Dario, Salachas, François, Camuzat, Agnes, Marchand‐Pauvert, Véronique, Cohen‐Adad, Julien, Colliot, Olivier, Le Ber, Isabelle, Pradat, Pierre‐François
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01.08.2019 Wiley Subscription Services, Inc Wiley
Subjects:	Adult Aged Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - diagnostic imaging Amyotrophic Lateral Sclerosis - genetics Anisotropy Asymptomatic Diseases Atrophy Bioengineering C9orf72 Protein - genetics Computer Science Computer Vision and Pattern Recognition Degeneration Dementia disorders Engineering Sciences Follow-Up Studies Frontotemporal dementia Frontotemporal Dementia - diagnostic imaging Frontotemporal Dementia - genetics Genetics Heterozygote Humans Image Processing Imaging Life Sciences Longitudinal Studies Magnetic resonance imaging Medical Imaging Middle Aged Mutation Mutation - genetics Neurobiology Neuroimaging Neuroimaging - trends Neurology Neurons and Cognition Parameters Prospective Studies Pyramidal tracts Signal and Image processing Spinal cord Spinal Cord - diagnostic imaging Subgroups Substantia grisea Tensors Vertebrae Young Adult
ISSN:	0364-5134, 1531-8249, 1531-8249
Online Access:	Get full text
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