Barrier function and natural moisturizing factor levels after cumulative exposure to a fruit-derived organic acid and a detergent: different outcomes in atopic and healthy skin and relevance for occupational contact dermatitis in the food industry

Fruit-derived organic compounds and detergents are relevant exposure factors for occupational contact dermatitis in the food industry. Although individuals with atopic dermatitis (AD) are at risk for development of occupational contact dermatitis, there have been no controlled studies on the effects...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Contact dermatitis Ročník 73; číslo 6; s. 358 - 363
Hlavní autoři: Angelova-Fischer, Irena, Hoek, Anne-Karin, Dapic, Irena, Jakasa, Ivone, Kezic, Sanja, Fischer, Tobias W., Zillikens, Detlef
Médium: Journal Article
Jazyk:angličtina
Vydáno: Oxford, UK Blackwell Publishing Ltd 01.12.2015
Wiley Subscription Services, Inc
Témata:
Acetic Acid - adverse effects
Adult
Aged
atopic dermatitis
Dermatitis
Dermatitis, Allergic Contact - etiology
Dermatitis, Allergic Contact - metabolism
Dermatitis, Occupational - etiology
Dermatitis, Occupational - metabolism
Detergents - adverse effects
Female
Food
Food Industry
Fruit
fruit-derived organic acids
Hand Dermatoses - chemically induced
Humans
irritant hand eczema
Male
Middle Aged
natural moisturizing factor
occupational contact dermatitis
Skin - metabolism
skin barrier function
Sodium Dodecyl Sulfate - adverse effects
sodium lauryl sulfate
Water Loss, Insensible
Young Adult
sodium lauryl sulfate
skin barrier function
irritant hand eczema
atopic dermatitis
occupational contact dermatitis
fruit-derived organic acids
natural moisturizing factor
ISSN:0105-1873, 1600-0536, 1600-0536
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Fruit-derived organic compounds and detergents are relevant exposure factors for occupational contact dermatitis in the food industry. Although individuals with atopic dermatitis (AD) are at risk for development of occupational contact dermatitis, there have been no controlled studies on the effects of repeated exposure to multiple irritants, relevant for the food industry, in atopic skin. The aim of the study was to investigate the outcomes of repeated exposure to a fruit-derived organic acid and a detergent in AD compared to healthy volunteers. The volunteers were exposed to 2.0% acetic acid (AcA) and/or 0.5% sodium lauryl sulfate (SLS) in controlled tandem repeated irritation test. The outcomes were assessed by measurements of erythema, transepidermal water loss (TEWL) and natural moisturizing factor (NMF) levels. In the AD volunteers, repeated AcA exposure led to barrier disruption and significant TEWL increase; no significant differences after the same exposure in the healthy controls were found. Repeated exposure to SLS and the irritant tandems enhanced the reactions and resulted in a significantly higher increase in TEWL in the AD compared to the control group. Cumulative irritant exposure reduced the NMF levels in both groups. Differences in the severity of irritant-induced barrier impairment in atopic individuals contribute to the risk for occupational contact dermatitis in result of multiple exposures to food-derived irritants and detergents.
Bibliografie:University of Lübeck
ArticleID:COD12464
istex:2835B0957EF1757FE7E825E117EACF8BE712FD53
ark:/67375/WNG-VCFQWHBG-Q
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0105-1873
1600-0536
1600-0536
DOI:10.1111/cod.12464