T-Cell Response to Viral Hemorrhagic Fevers

Viral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families Arenaviridae, Filoviridae, Hantaviridae, and Flaviviridae. Clinically, this group of diseases has in common fever, fatigue, dizziness, muscle aches, and o...

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Vydáno v:Vaccines (Basel) Ročník 7; číslo 1; s. 11
Hlavní autoři: Perdomo-Celis, Federico, Salvato, Maria S., Medina-Moreno, Sandra, Zapata, Juan C.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 22.01.2019
MDPI
Témata:
Dengue fever
dengue virus
Dizziness
Ebola virus
Fatalities
Fever
hantavirus
Hemorrhage
Immune response
Immune response (cell-mediated)
Infectious diseases
interferon-gamma
Lassa virus
Lymphocytes T
Muscles
Muscular fatigue
Pathogenesis
Review
RNA viruses
Signs and symptoms
T-cells
tumor necrosis factor-alpha
vaccine
viral hemorrhagic fever
Viruses
yellow fever virus
Brazil
United States > US
West Africa
Africa
Ebola virus
T-cells
tumor necrosis factor-alpha
vaccine
yellow fever virus
hantavirus
dengue virus
viral hemorrhagic fever
Lassa virus
interferon-gamma
ISSN:2076-393X, 2076-393X
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Abstract Viral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families Arenaviridae, Filoviridae, Hantaviridae, and Flaviviridae. Clinically, this group of diseases has in common fever, fatigue, dizziness, muscle aches, and other associated symptoms that can progress to vascular leakage, bleeding and multi-organ failure. Most of these viruses are zoonotic causing asymptomatic infections in the primary host, but in human beings, the infection can be lethal. Clinical and experimental evidence suggest that the T-cell response is needed for protection against VHF, but can also cause damage to the host, and play an important role in disease pathogenesis. Here, we present a review of the T-cell immune responses to VHF and insights into the possible ways to improve counter-measures for these viral agents.
AbstractList Viral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families Arenaviridae, Filoviridae, Hantaviridae, and Flaviviridae. Clinically, this group of diseases has in common fever, fatigue, dizziness, muscle aches, and other associated symptoms that can progress to vascular leakage, bleeding and multi-organ failure. Most of these viruses are zoonotic causing asymptomatic infections in the primary host, but in human beings, the infection can be lethal. Clinical and experimental evidence suggest that the T-cell response is needed for protection against VHF, but can also cause damage to the host, and play an important role in disease pathogenesis. Here, we present a review of the T-cell immune responses to VHF and insights into the possible ways to improve counter-measures for these viral agents.
Viral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families Arenaviridae, Filoviridae, Hantaviridae, and Flaviviridae. Clinically, this group of diseases has in common fever, fatigue, dizziness, muscle aches, and other associated symptoms that can progress to vascular leakage, bleeding and multi-organ failure. Most of these viruses are zoonotic causing asymptomatic infections in the primary host, but in human beings, the infection can be lethal. Clinical and experimental evidence suggest that the T-cell response is needed for protection against VHF, but can also cause damage to the host, and play an important role in disease pathogenesis. Here, we present a review of the T-cell immune responses to VHF and insights into the possible ways to improve counter-measures for these viral agents.Viral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families Arenaviridae, Filoviridae, Hantaviridae, and Flaviviridae. Clinically, this group of diseases has in common fever, fatigue, dizziness, muscle aches, and other associated symptoms that can progress to vascular leakage, bleeding and multi-organ failure. Most of these viruses are zoonotic causing asymptomatic infections in the primary host, but in human beings, the infection can be lethal. Clinical and experimental evidence suggest that the T-cell response is needed for protection against VHF, but can also cause damage to the host, and play an important role in disease pathogenesis. Here, we present a review of the T-cell immune responses to VHF and insights into the possible ways to improve counter-measures for these viral agents.
Viral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families , , , and . Clinically, this group of diseases has in common fever, fatigue, dizziness, muscle aches, and other associated symptoms that can progress to vascular leakage, bleeding and multi-organ failure. Most of these viruses are zoonotic causing asymptomatic infections in the primary host, but in human beings, the infection can be lethal. Clinical and experimental evidence suggest that the T-cell response is needed for protection against VHF, but can also cause damage to the host, and play an important role in disease pathogenesis. Here, we present a review of the T-cell immune responses to VHF and insights into the possible ways to improve counter-measures for these viral agents.
Author Zapata, Juan C.
Perdomo-Celis, Federico
Medina-Moreno, Sandra
Salvato, Maria S.
AuthorAffiliation 1 Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Medellín 050010, Colombia; fcelis@ihv.umaryland.edu or federico.perdomo@usco.edu.co
2 Institute of Human Virology, School of Medicine, University of Maryland; Baltimore, MD 21201, USA; msalvato@ihv.umaryland.edu (M.S.S.); smmoreno@ihv.umaryland.edu (S.M.-M.)
AuthorAffiliation_xml – name: 2 Institute of Human Virology, School of Medicine, University of Maryland; Baltimore, MD 21201, USA; msalvato@ihv.umaryland.edu (M.S.S.); smmoreno@ihv.umaryland.edu (S.M.-M.)
– name: 1 Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Medellín 050010, Colombia; fcelis@ihv.umaryland.edu or federico.perdomo@usco.edu.co
Author_xml – sequence: 1
  givenname: Federico
  orcidid: 0000-0003-0119-8306
  surname: Perdomo-Celis
  fullname: Perdomo-Celis, Federico
– sequence: 2
  givenname: Maria S.
  surname: Salvato
  fullname: Salvato, Maria S.
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  givenname: Sandra
  surname: Medina-Moreno
  fullname: Medina-Moreno, Sandra
– sequence: 4
  givenname: Juan C.
  orcidid: 0000-0003-1931-6147
  surname: Zapata
  fullname: Zapata, Juan C.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30678246$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords Ebola virus
T-cells
tumor necrosis factor-alpha
vaccine
yellow fever virus
hantavirus
dengue virus
viral hemorrhagic fever
Lassa virus
interferon-gamma
Language English
License Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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Snippet Viral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families Arenaviridae,...
Viral hemorrhagic fevers (VHF) are a group of clinically similar diseases that can be caused by enveloped RNA viruses primarily from the families , , , and ....
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SubjectTerms Dengue fever
dengue virus
Dizziness
Ebola virus
Fatalities
Fever
hantavirus
Hemorrhage
Immune response
Immune response (cell-mediated)
Infectious diseases
interferon-gamma
Lassa virus
Lymphocytes T
Muscles
Muscular fatigue
Pathogenesis
Review
RNA viruses
Signs and symptoms
T-cells
tumor necrosis factor-alpha
vaccine
viral hemorrhagic fever
Viruses
yellow fever virus
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Title T-Cell Response to Viral Hemorrhagic Fevers
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