Viral diversity and dynamics in an infant gut

Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral s...

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Vydáno v:Research in microbiology Ročník 159; číslo 5; s. 367 - 373
Hlavní autoři: Breitbart, Mya, Haynes, Matthew, Kelley, Scott, Angly, Florent, Edwards, Robert A., Felts, Ben, Mahaffy, Joseph M., Mueller, Jennifer, Nulton, James, Rayhawk, Steve, Rodriguez-Brito, Beltran, Salamon, Peter, Rohwer, Forest
Médium: Journal Article Konferenční příspěvek
Jazyk:angličtina
Vydáno: Paris Elsevier SAS 01.06.2008
Elsevier
Témata:
Biodiversity
Biological and medical sciences
DNA Viruses - classification
DNA Viruses - genetics
DNA Viruses - isolation & purification
DNA Viruses - ultrastructure
DNA, Viral - genetics
Feces
Feces - virology
Fundamental and applied biological sciences. Psychology
Gastrointestinal Tract - virology
Gut
Humans
Infant
Infant Food - analysis
Male
Metagenomics
Microarray
Microbiology
Miscellaneous
Molecular Sequence Data
Oligonucleotide Array Sequence Analysis
Phage
Virology
Virus
Virus
Metagenomics
Gut
Infant
Feces
Microarray
Phage
Human
Microbiology
Digestive system
ISSN:0923-2508, 1769-7123
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Shrnutí:Metagenomic sequencing of DNA viruses from the feces of a healthy week-old infant revealed a viral community with extremely low diversity. The identifiable sequences were dominated by phages, which likely influence the diversity and abundance of co-occurring microbes. The most abundant fecal viral sequences did not originate from breast milk or formula, suggesting a non-dietary initial source of viruses. Certain sequences were stable in the infant's gut over the first 3 months of life, but microarray experiments demonstrated that the overall viral community composition changed dramatically between 1 and 2 weeks of age.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0923-2508
1769-7123
DOI:10.1016/j.resmic.2008.04.006