The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

Here, we propose a new model for understanding the Warburg effect in tumor metabolism. Our hypothesis is that epithelial cancer cells induce the Warburg effect (aerobic glycolysis) in neighboring stromal fibroblasts. These cancer-associated fibroblasts, then undergo myo-fibroblastic differentiation...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 8; no. 23; pp. 3984 - 4001
Main Authors:	Pavlides, Stephanos, Whitaker-Menezes, Diana, Castello-Cros, Remedios, Flomenberg, Neal, Witkiewicz, Agnieszka K., Frank, Philippe G., Casimiro, Mathew C., Wang, Chenguang, Fortina, Paolo, Addya, Sankar, Pestell, Richard G., Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01.12.2009
Subjects:	Animals Annexins - metabolism Binding Biology Bioscience Breast Neoplasms - metabolism Calcium Cancer Caveolin 1 - deficiency Caveolin 1 - genetics Caveolin 1 - metabolism Cell Cycle Female Fibroblasts - metabolism Glycolysis Humans L-Lactate Dehydrogenase - metabolism Landes Mice Mice, Knockout Organogenesis Proteins Proteomics Pyruvate Kinase - metabolism Stromal Cells - metabolism Tenascin - metabolism Up-Regulation
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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