Rab6 regulates transport and targeting of exocytotic carriers

Constitutive exocytosis delivers newly synthesized proteins, lipids, and other molecules from the Golgi apparatus to the cell surface. This process is mediated by vesicles, which bud off the trans-Golgi network, move along cytoskeletal filaments, and fuse with the plasma membrane. Here, we show that...

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Vydáno v:Developmental cell Ročník 13; číslo 2; s. 305
Hlavní autoři: Grigoriev, Ilya, Splinter, Daniël, Keijzer, Nanda, Wulf, Phebe S, Demmers, Jeroen, Ohtsuka, Toshihisa, Modesti, Mauro, Maly, Ivan V, Grosveld, Frank, Hoogenraad, Casper C, Akhmanova, Anna
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.08.2007
Témata:
Adaptor Proteins, Signal Transducing - metabolism
Animals
Biological Transport
Biomarkers - metabolism
Cell Line
Cell Membrane - metabolism
Cytoplasm - metabolism
Dogs
Dyneins - metabolism
Exocytosis
HeLa Cells
Humans
Kinesin - metabolism
Membrane Fusion
Nerve Tissue Proteins - metabolism
rab GTP-Binding Proteins - metabolism
Rats
Transport Vesicles - metabolism
ISSN:1534-5807
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Shrnutí:Constitutive exocytosis delivers newly synthesized proteins, lipids, and other molecules from the Golgi apparatus to the cell surface. This process is mediated by vesicles, which bud off the trans-Golgi network, move along cytoskeletal filaments, and fuse with the plasma membrane. Here, we show that the small GTPase Rab6 marks exocytotic vesicles and, together with the microtubule plus-end-directed motor kinesin-1, stimulates their processive microtubule-based transport to the cell periphery. Furthermore, Rab6 directs targeting of secretory vesicles to plasma-membrane sites enriched in the cortical protein ELKS, a known Rab6 binding partner. Our data demonstrate that although Rab6 is not essential for secretion, it controls the organization of exocytosis within the cellular space.
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ISSN:1534-5807
DOI:10.1016/j.devcel.2007.06.010