Predicting human neurotoxicity of propylene glycol methyl ether (PGME) by implementing in vitro neurotoxicity results into toxicokinetic modelling

Although organic solvents have been associated with CNS toxicity, neurotoxicity testing is rarely a regulatory requirement. We propose a strategy to assess the potential neurotoxicity of organic solvents and predict solvent air concentrations that will not likely produce neurotoxicity in exposed ind...

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Bibliographic Details
Published in:	The Science of the total environment Vol. 886; p. 163767
Main Authors:	Reale, E., Sandstrom, J., Culot, M., Hechon, J., Wellens, S., Heymans, M., Tschudi-Monnet, F., Vernez, D., Hopf, N.B.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15.08.2023 Elsevier
Subjects:	1-Methoxypropan-2-ol adverse effects air biomarkers blood-brain barrier brain CNS computer simulation cytokines environment ethylene glycol Glycol ethers humans inflammation IVIVE Life Sciences metabolites methyl ethers neurons neurotoxicity occupational exposure PBPK permeability propylene glycol Solvent neurotoxicity solvents PBPK CNS Solvent neurotoxicity 1-Methoxypropan-2-ol Glycol ethers IVIVE
ISSN:	0048-9697, 1879-1026, 1879-1026
Online Access:	Get full text
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