AF-2 activity and recruitment of steroid receptor coactivator 1 to the estrogen receptor depend on a lysine residue conserved in nuclear receptors

Hormone-dependent transcriptional activation by nuclear receptors depends on the presence of a conserved C-terminal amphipathic alpha-helix (helix 12) in the ligand-binding domain. Here we show that a lysine residue, which is conserved in most nuclear receptors in the predicted helix 3, is also requ...

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Bibliographic Details
Published in:	Molecular and cellular biology Vol. 17; no. 4; p. 1832
Main Authors:	Henttu, P M, Kalkhoven, E, Parker, M G
Format:	Journal Article
Language:	English
Published:	United States 01.04.1997
Subjects:	Adaptor Proteins, Signal Transducing Amino Acid Sequence Animals Base Sequence Cell Line Conserved Sequence Histone Acetyltransferases Humans Lysine - genetics Mice Molecular Sequence Data Mutagenesis, Site-Directed Nuclear Proteins - metabolism Nuclear Receptor Coactivator 1 Nuclear Receptor Coactivator 2 Nuclear Receptor Interacting Protein 1 Oligodeoxyribonucleotides - genetics Receptors, Cytoplasmic and Nuclear - chemistry Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Estrogen - metabolism Sequence Homology, Amino Acid Transcription Factors - metabolism Transcriptional Activation
ISSN:	0270-7306
Online Access:	Get more information
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