Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

In the adult brain, the neural stem cell (NSC) pool comprises quiescent and activated populations with distinct roles. Transcriptomic analysis revealed that quiescent and activated NSCs exhibited differences in their protein homeostasis network. Whereas activated NSCs had active proteasomes, quiesce...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 359; H. 6381; S. 1277
Hauptverfasser:	Leeman, Dena S, Hebestreit, Katja, Ruetz, Tyson, Webb, Ashley E, McKay, Andrew, Pollina, Elizabeth A, Dulken, Ben W, Zhao, Xiaoai, Yeo, Robin W, Ho, Theodore T, Mahmoudi, Salah, Devarajan, Keerthana, Passegué, Emmanuelle, Rando, Thomas A, Frydman, Judith, Brunet, Anne
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 16.03.2018
Schlagworte:	Aging - physiology Animals Cell Division Cellular Senescence Lysosomes - physiology Mice Mice, Inbred C57BL Neural Stem Cells - physiology
ISSN:	1095-9203, 1095-9203
Online-Zugang:	Weitere Angaben
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