Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function

Understanding gene function and regulation in homeostasis and disease requires knowledge of the cellular and tissue contexts in which genes are expressed. Here, we applied four single-nucleus RNA sequencing methods to eight diverse, archived, frozen tissue types from 16 donors and 25 samples, genera...

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Vydáno v:	Science (American Association for the Advancement of Science) Ročník 376; číslo 6594; s. eabl4290
Hlavní autoři:	Eraslan, Gökcen, Drokhlyansky, Eugene, Anand, Shankara, Fiskin, Evgenij, Subramanian, Ayshwarya, Slyper, Michal, Wang, Jiali, Van Wittenberghe, Nicholas, Rouhana, John M, Waldman, Julia, Ashenberg, Orr, Lek, Monkol, Dionne, Danielle, Win, Thet Su, Cuoco, Michael S, Kuksenko, Olena, Tsankov, Alexander M, Branton, Philip A, Marshall, Jamie L, Greka, Anna, Getz, Gad, Segrè, Ayellet V, Aguet, François, Rozenblatt-Rosen, Orit, Ardlie, Kristin G, Regev, Aviv
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 13.05.2022
Témata:	Biomarkers Cell Nucleus - genetics Disease - genetics Genome-Wide Association Study Humans Organ Specificity Phenotype RNA-Seq - methods
ISSN:	1095-9203, 1095-9203
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