Succination inactivates gasdermin D and blocks pyroptosis

Activated macrophages undergo a metabolic switch to aerobic glycolysis, accumulating Krebs' cycle intermediates that alter transcription of immune response genes. We extended these observations by defining fumarate as an inhibitor of pyroptotic cell death. We found that dimethyl fumarate (DMF)...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 369; H. 6511; S. 1633
Hauptverfasser:	Humphries, Fiachra, Shmuel-Galia, Liraz, Ketelut-Carneiro, Natalia, Li, Sheng, Wang, Bingwei, Nemmara, Venkatesh V, Wilson, Ruth, Jiang, Zhaozhao, Khalighinejad, Farnaz, Muneeruddin, Khaja, Shaffer, Scott A, Dutta, Ranjan, Ionete, Carolina, Pesiridis, Scott, Yang, Shuo, Thompson, Paul R, Fitzgerald, Katherine A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 25.09.2020
Schlagworte:	Animals Caspases - metabolism Citric Acid Cycle - drug effects Cysteine - analogs & derivatives Cysteine - metabolism Dimethyl Fumarate - pharmacology Dimethyl Fumarate - therapeutic use Encephalomyelitis, Autoimmune, Experimental - drug therapy Familial Mediterranean Fever - drug therapy Female HEK293 Cells Humans Inflammasomes - drug effects Inflammasomes - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Lipopolysaccharides - immunology Macrophage Activation Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Male Mice Mice, Inbred C57BL Mice, Mutant Strains Multiple Sclerosis - drug therapy Phosphate-Binding Proteins - genetics Phosphate-Binding Proteins - metabolism Protein Processing, Post-Translational Pyroptosis - drug effects Pyroptosis - immunology
ISSN:	1095-9203, 1095-9203
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