miR-491 Inhibits Osteosarcoma Lung Metastasis and Chemoresistance by Targeting αB-crystallin

Dysregulated microRNAs (miRNAs) play an important role in osteosarcoma (OS) progression. In the present study, we investigate the clinical significance of serum miR-491 level and the potential role of miR-491 in OS lung metastasis and chemoresistance. Clinical data show that the level of miR-491 was...

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Bibliographic Details
Published in:	Molecular therapy Vol. 25; no. 9; pp. 2140 - 2149
Main Authors:	Wang, Shu-Nan, Luo, Song, Liu, Chang, Piao, Zhenghao, Gou, Wenlong, Wang, Yun, Guan, Wei, Li, Qing, Zou, Hua, Yang, Zhen-Zhou, Wang, Dong, Wang, Yan, Xu, Meng, Jin, Hua, Xu, Cheng-Xiong
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 06.09.2017 Elsevier Limited American Society of Gene & Cell Therapy
Subjects:	alpha-Crystallin B Chain - genetics Apoptosis Biomarkers Bone cancer Bone Neoplasms - drug therapy Bone Neoplasms - genetics Bone Neoplasms - mortality Bone Neoplasms - pathology Cell Line, Tumor Cell Proliferation Chemoresistance Chemotherapy Circulating MicroRNA Cisplatin Conflicts of interest CRYAB Crystallin Drug Resistance, Neoplasm - genetics Gene expression Gene Expression Regulation, Neoplastic Growth inhibition Humans Lung cancer Lung Neoplasms - secondary Lungs Medical prognosis Metastases Metastasis MicroRNAs - blood MicroRNAs - genetics miRNA Neoplasm Metastasis Neoplasm Staging Original Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - genetics Osteosarcoma - mortality Osteosarcoma - pathology osteosarcoma metastasis Patients Prognosis Proteins RNA Interference Sarcoma Survival analysis China miRNA chemoresistance osteosarcoma metastasis CRYAB
ISSN:	1525-0016, 1525-0024, 1525-0024
Online Access:	Get full text
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