Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos

Genomic imprinting regulates parental-specific expression of particular genes and is required for normal mammalian development. How imprinting is established during development is, however, largely unknown. To address this question, we studied the mouse Kcnq1 imprinted cluster at which paternal-spec...

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Vydáno v:	Developmental cell Ročník 15; číslo 5; s. 668
Hlavní autoři:	Terranova, Rémi, Yokobayashi, Shihori, Stadler, Michael B, Otte, Arie P, van Lohuizen, Maarten, Orkin, Stuart H, Peters, Antoine H F M
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.11.2008
Témata:	Animals Cell Nucleus - genetics Cell Nucleus - metabolism Chromatin Assembly and Disassembly DNA-Binding Proteins - metabolism Embryo, Mammalian - metabolism Enhancer of Zeste Homolog 2 Protein Female Genomic Imprinting Histone-Lysine N-Methyltransferase - metabolism Male Mice Polycomb Repressive Complex 1 Polycomb Repressive Complex 2 Repressor Proteins - metabolism RNA, Long Noncoding RNA, Untranslated - metabolism Ubiquitin-Protein Ligases - metabolism
ISSN:	1878-1551, 1878-1551
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