Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate

Cerebral small vessel disease is a leading cause of stroke and a major contributor to cognitive decline and dementia, but our understanding of specific genes underlying the cause of sporadic cerebral small vessel disease is limited. We report a genome-wide association study and a whole-exome associa...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Brain (London, England : 1878) Jg. 145; H. 6; S. 1992
Hauptverfasser:	Mishra, Aniket, Duplaà, Cécile, Vojinovic, Dina, Suzuki, Hideaki, Sargurupremraj, Muralidharan, Zilhão, Nuno R, Li, Shuo, Bartz, Traci M, Jian, Xueqiu, Zhao, Wei, Hofer, Edith, Wittfeld, Katharina, Harris, Sarah E, van der Auwera-Palitschka, Sandra, Luciano, Michelle, Bis, Joshua C, Adams, Hieab H H, Satizabal, Claudia L, Gottesman, Rebecca F, Gampawar, Piyush G, Bülow, Robin, Weiss, Stefan, Yu, Miao, Bastin, Mark E, Lopez, Oscar L, Vernooij, Meike W, Beiser, Alexa S, Völker, Uwe, Kacprowski, Tim, Soumare, Aicha, Smith, Jennifer A, Knopman, David S, Morris, Zoe, Zhu, Yicheng, Rotter, Jerome I, Dufouil, Carole, Valdés Hernández, Maria, Muñoz Maniega, Susana, Lathrop, Mark, Boerwinkle, Erik, Schmidt, Reinhold, Ihara, Masafumi, Mazoyer, Bernard, Yang, Qiong, Joutel, Anne, Tournier-Lasserve, Elizabeth, Launer, Lenore J, Deary, Ian J, Mosley, Thomas H, Amouyel, Philippe, DeCarli, Charles S, Psaty, Bruce M, Tzourio, Christophe, Kardia, Sharon L R, Grabe, Hans J, Teumer, Alexander, van Duijn, Cornelia M, Schmidt, Helena, Wardlaw, Joanna M, Ikram, M Arfan, Fornage, Myriam, Gudnason, Vilmundur, Seshadri, Sudha, Matthews, Paul M, Longstreth, William T, Couffinhal, Thierry, Debette, Stephanie
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 30.06.2022
Schlagworte:	Animals Brain Ischemia - complications Cerebral Small Vessel Diseases - complications Cerebral Small Vessel Diseases - diagnostic imaging Cerebral Small Vessel Diseases - genetics Endothelial Cells - pathology Genome-Wide Association Study Mice Stroke - complications TRIM47 cerebral small vessel disease endothelial cells GWAS whole-exome association study
ISSN:	1460-2156, 1460-2156
Online-Zugang:	Weitere Angaben
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!