Three-dimensional intact-tissue sequencing of single-cell transcriptional states

Retrieving high-content gene-expression information while retaining three-dimensional (3D) positional anatomy at cellular resolution has been difficult, limiting integrative understanding of structure and function in complex biological tissues. We developed and applied a technology for 3D intact-tis...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 361; no. 6400
Main Authors:	Wang, Xiao, Allen, William E, Wright, Matthew A, Sylwestrak, Emily L, Samusik, Nikolay, Vesuna, Sam, Evans, Kathryn, Liu, Cindy, Ramakrishnan, Charu, Liu, Jia, Nolan, Garry P, Bava, Felice-Alessio, Deisseroth, Karl
Format:	Journal Article
Language:	English
Published:	United States 27.07.2018
Subjects:	Animals Chromosome Mapping Frontal Lobe - cytology Frontal Lobe - metabolism Imaging, Three-Dimensional Male Mice Mice, Inbred C57BL Molecular Imaging Neurons - metabolism Sequence Analysis, RNA - methods Single-Cell Analysis - methods Somatosensory Cortex - cytology Somatosensory Cortex - metabolism Transcription, Genetic Transcriptome Visual Cortex - cytology Visual Cortex - metabolism
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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