Decoding the selective chemical modulation of CYP3A4

Drug-drug interactions associate with concurrent uses of multiple medications. Cytochrome P450 (CYP) 3A4 metabolizes a large portion of marketed drugs. To maintain the efficacy of drugs metabolized by CYP3A4, pan-CYP3A inhibitors such as ritonavir are often co-administered. Although selective CYP3A4...

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Bibliographic Details
Published in:	Nature communications Vol. 16; no. 1; pp. 3423 - 19
Main Authors:	Wang, Jingheng, Nithianantham, Stanley, Chai, Sergio C., Jung, Young-Hwan, Yang, Lei, Ong, Han Wee, Li, Yong, Zhang, Yifan, Miller, Darcie J., Chen, Taosheng
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10.04.2025 Nature Publishing Group Nature Portfolio
Subjects:	13/106 38/47 631/154/1435/2163 631/535/1266 631/92/609 639/638/92/607 82/80 82/83 Binding Cytochrome P-450 CYP3A - chemistry Cytochrome P-450 CYP3A - genetics Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 CYP3A Inhibitors - chemistry Cytochrome P-450 CYP3A Inhibitors - pharmacology Cytochrome P450 Cytochromes P450 Drug interaction Drug Interactions Drugs Effectiveness High-throughput screening High-Throughput Screening Assays Homology Humanities and Social Sciences Humans Inhibitors Ligands multidisciplinary Protein Binding Ritonavir Science Science (multidisciplinary) Structure-function relationships
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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