A review of treatment for retinopathy of prematurity

Introduction: Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide. Areas covered: Recent methods to identify and manage treatment-warranted vascularly active ROP are recognized and being compared to standard care by laser treatment in prospective large-scale clinical...

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Bibliographic Details
Published in:Expert review of ophthalmology Vol. 14; no. 2; pp. 73 - 87
Main Authors: Hansen, Eric D., Hartnett, M. Elizabeth
Format: Journal Article
Language:English
Published: England Taylor & Francis 04.03.2019
Subjects:
angiogenesis
laser
lens-sparing
retinal detachment
Retinopathy of prematurity (ROP)
scleral buckle
stage 4 or 5 ROP
surgical outcomes
vascular endothelial growth factor inhibitors (anti-VEGF)
vitrectomy
lens-sparing
retinopathy of prematurity (ROP)
laser
surgical outcomes
angiogenesis
vascular endothelial growth factor inhibitors (anti-VEGF)
vitrectomy
scleral buckle
retinal detachment
stage 4 or 5 ROP
ISSN:1746-9899, 1746-9902
Online Access:Get full text
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Summary:Introduction: Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide. Areas covered: Recent methods to identify and manage treatment-warranted vascularly active ROP are recognized and being compared to standard care by laser treatment in prospective large-scale clinical studies. Pharmacologic anti-angiogenic (anti-VEGF) treatment has changed the natural history of vascularly active ROP by reducing stage 3 intravitreal neovascularization and extending physiologic retinal vascularization in many infants. Tractional retinal detachments in stage 4 ROP after treatment with anti-VEGF agents show additional fibrovascular complexity compared to eyes treated with laser only. We review current management and outcomes for vascularly active and fibrovascular retinal detachment in ROP (stages 3, 4, 5 ROP), highlighting the evidence from recent clinical studies. Included are technical details important in surgery for retinal detachment in ROP. Literature searches were employed through PubMed. Expert opinion: Experimental studies in basic mechanisms, methods in pediatric imaging, safer pharmacologic treatments, and surgical techniques continue to advance to improve future ROP outcomes.
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ISSN:1746-9899
1746-9902
DOI:10.1080/17469899.2019.1596026