Cell competition during reprogramming gives rise to dominant clones

The ability to generate induced pluripotent stem cells from differentiated cell types has enabled researchers to engineer cell states. Although studies have identified molecular networks that reprogram cells to pluripotency, the cellular dynamics of these processes remain poorly understood. Here, by...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 364; H. 6438
Hauptverfasser:	Shakiba, Nika, Fahmy, Ahmed, Jayakumaran, Gowtham, McGibbon, Sophie, David, Laurent, Trcka, Daniel, Elbaz, Judith, Puri, Mira C, Nagy, Andras, van der Kooy, Derek, Goyal, Sidhartha, Wrana, Jeffrey L, Zandstra, Peter W
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 26.04.2019
Schlagworte:	Animals Cellular Reprogramming - genetics Cellular Reprogramming - physiology Cellular Reprogramming Techniques Clonal Evolution Clone Cells - cytology DNA - genetics Fibroblasts - cytology Induced Pluripotent Stem Cells - cytology Mice Models, Theoretical
ISSN:	1095-9203, 1095-9203
Online-Zugang:	Weitere Angaben
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