Replication timing maintains the global epigenetic state in human cells

The temporal order of DNA replication [replication timing (RT)] is correlated with chromatin modifications and three-dimensional genome architecture; however, causal links have not been established, largely because of an inability to manipulate the global RT program. We show that loss of RIF1 causes...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 372; no. 6540; p. 371
Main Authors:	Klein, Kyle N, Zhao, Peiyao A, Lyu, Xiaowen, Sasaki, Takayo, Bartlett, Daniel A, Singh, Amar M, Tasan, Ipek, Zhang, Meng, Watts, Lotte P, Hiraga, Shin-Ichiro, Natsume, Toyoaki, Zhou, Xuemeng, Baslan, Timour, Leung, Danny, Kanemaki, Masato T, Donaldson, Anne D, Zhao, Huimin, Dalton, Stephen, Corces, Victor G, Gilbert, David M
Format:	Journal Article
Language:	English
Published:	United States 23.04.2021
Subjects:	Cell Line Chromatin - metabolism Chromatin Assembly and Disassembly DNA Replication DNA Replication Timing Epigenesis, Genetic Epigenome Gene Expression Gene Knockout Techniques Genome, Human Heterochromatin - metabolism Histone Code Histones - metabolism Humans Telomere-Binding Proteins - genetics Telomere-Binding Proteins - metabolism
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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