The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans
Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. We created a human reference atlas comprising nearly 500,000 cells from 24 different tissues and organs, many from the sa...
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| Vydané v: | Science (American Association for the Advancement of Science) Ročník 376; číslo 6594; s. eabl4896 |
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| Hlavní autori: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
United States
13.05.2022
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| Predmet: | |
| ISSN: | 1095-9203, 1095-9203 |
| On-line prístup: | Zistit podrobnosti o prístupe |
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| Abstract | Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. We created a human reference atlas comprising nearly 500,000 cells from 24 different tissues and organs, many from the same donor. This atlas enabled molecular characterization of more than 400 cell types, their distribution across tissues, and tissue-specific variation in gene expression. Using multiple tissues from a single donor enabled identification of the clonal distribution of T cells between tissues, identification of the tissue-specific mutation rate in B cells, and analysis of the cell cycle state and proliferative potential of shared cell types across tissues. Cell type-specific RNA splicing was discovered and analyzed across tissues within an individual. |
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| AbstractList | Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. We created a human reference atlas comprising nearly 500,000 cells from 24 different tissues and organs, many from the same donor. This atlas enabled molecular characterization of more than 400 cell types, their distribution across tissues, and tissue-specific variation in gene expression. Using multiple tissues from a single donor enabled identification of the clonal distribution of T cells between tissues, identification of the tissue-specific mutation rate in B cells, and analysis of the cell cycle state and proliferative potential of shared cell types across tissues. Cell type-specific RNA splicing was discovered and analyzed across tissues within an individual.Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. We created a human reference atlas comprising nearly 500,000 cells from 24 different tissues and organs, many from the same donor. This atlas enabled molecular characterization of more than 400 cell types, their distribution across tissues, and tissue-specific variation in gene expression. Using multiple tissues from a single donor enabled identification of the clonal distribution of T cells between tissues, identification of the tissue-specific mutation rate in B cells, and analysis of the cell cycle state and proliferative potential of shared cell types across tissues. Cell type-specific RNA splicing was discovered and analyzed across tissues within an individual. Molecular characterization of cell types using single-cell transcriptome sequencing is revolutionizing cell biology and enabling new insights into the physiology of human organs. We created a human reference atlas comprising nearly 500,000 cells from 24 different tissues and organs, many from the same donor. This atlas enabled molecular characterization of more than 400 cell types, their distribution across tissues, and tissue-specific variation in gene expression. Using multiple tissues from a single donor enabled identification of the clonal distribution of T cells between tissues, identification of the tissue-specific mutation rate in B cells, and analysis of the cell cycle state and proliferative potential of shared cell types across tissues. Cell type-specific RNA splicing was discovered and analyzed across tissues within an individual. |
| Author | Crasta, Sheela Concepcion, Waldo Vijayakumar, Sivakamasundari Neuhöfer, Patrick Huang, Xianxi Steffes, Lea C Jang, SoRi Li, Baoxiang Aaron, Ksenia A Kong, William Colville, Alex Puluca, Nazan Neidlinger, Nikole Van Treuren, Will Raquer-McKay, Hayley Antony, Jane Mantri, Sruthi Goodyer, William R Gardner, James M Kelly, Burnett McAlpine, Patrick L Weinstein, Hannah N W Xie, Jamie Ezran, Camille Wu, Timothy T H Alcántara-Hernández, Marcela Spallino, Eileen Ponnusamy, Ravikumar Pisco, Angela Oliveira Swarup, Aditi Veizades, Stefan Bulthaup, Bryan Vorperian, Sevahn K Salehi, Ahmad Kumar, Maya E Chang, Charles A Carter, Matthew M Spencer, Sean P Trimm, Emily Tan, Serena Y D'Amato, Gaetano Markovic, Maxim Quake, Stephen R Wang, Wanxin Hayashi, Alyssa Morri, Maurizio Calcuttawala, Kruti Zhang, Yue Seddighzadeh, Bobak Subramaniam, Varun R Galdos, Francisco X Kiss, Bernhard Almanzar, Nicole Swift, Michael Qi, Zhen Brown, Phillip Loeb, Gabriel B Harper, William Vo, Kim Chi Hemenez, Marisa Yung, Andrea R Krasnow, Mark A Lu, Wan-Jin Mrouj, Karim Detweiler, Ang |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35549404$$D View this record in MEDLINE/PubMed |
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| References | 36198687 - Signal Transduct Target Ther. 2022 Oct 5;7(1):352. doi: 10.1038/s41392-022-01201-w. 36039543 - Am J Transplant. 2022 Sep;22(9):2127-2128. doi: 10.1111/ajt.16671. |
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| Title | The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans |
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