Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death

Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming fragment that controls pyroptosis in macrophages. GSDMD is processed via inflammasome-activated caspase-1 or -11. It is currently unknown whether macrophage GSDMD can be processed by other mechanisms. Here, we describe a...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 362; H. 6418; S. 1064
Hauptverfasser:	Orning, Pontus, Weng, Dan, Starheim, Kristian, Ratner, Dmitry, Best, Zachary, Lee, Bettina, Brooks, Alexandria, Xia, Shiyu, Wu, Hao, Kelliher, Michelle A, Berger, Scott B, Gough, Peter J, Bertin, John, Proulx, Megan M, Goguen, Jon D, Kayagaki, Nobuhiko, Fitzgerald, Katherine A, Lien, Egil
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 30.11.2018
Schlagworte:	Animals Apoptosis Regulatory Proteins - metabolism Bacterial Proteins - metabolism Caspase 8 - genetics Caspase 8 - metabolism Cell Death Host-Pathogen Interactions Humans I-kappa B Kinase - metabolism Inflammasomes - immunology MAP Kinase Kinase Kinases - metabolism Mice Mice, Inbred C57BL NLR Family, Pyrin Domain-Containing 3 Protein Plague - enzymology Plague - immunology Plague - pathology Proteolysis
ISSN:	1095-9203, 1095-9203
Online-Zugang:	Weitere Angaben
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