The importance of small samples in medical research

Almost all bio-statisticians and medical researchers believe that a large sample is always helpful in providing more reliable results. Whereas this is true for some specific cases, a large sample may not be helpful in more situations than we contemplate because of the higher possibility of errors an...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Journal of postgraduate medicine Ročník 67; číslo 4; s. 219 - 223
Hlavní autoři: Indrayan, A, Mishra, A
Médium: Journal Article
Jazyk:angličtina
Vydáno: India Wolters Kluwer India Pvt. Ltd 01.10.2021
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer - Medknow
Témata:
Biomedical Research
Education Forum
Humans
Medical research
Sample Size
Medical research
n = 1
self-experiments
small sample
n= 1 self-experiments
ISSN:0022-3859, 0972-2823, 0972-2823
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Almost all bio-statisticians and medical researchers believe that a large sample is always helpful in providing more reliable results. Whereas this is true for some specific cases, a large sample may not be helpful in more situations than we contemplate because of the higher possibility of errors and reduced validity. Many medical breakthroughs have occurred with self-experimentation and single experiments. Studies, particularly analytical studies, may provide more truthful results with a small sample because intensive efforts can be made to control all the confounders, wherever they operate, and sophisticated equipment can be used to obtain more accurate data. A large sample may be required only for the studies with highly variable outcomes, where an estimate of the effect size with high precision is required, or when the effect size to be detected is small. This communication underscores the importance of small samples in reaching a valid conclusion in certain situations and describes the situations where a large sample is not only unnecessary but may even compromise the validity by not being able to exercise full care in the assessments. What sample size is small depends on the context.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0022-3859
0972-2823
0972-2823
DOI:10.4103/jpgm.JPGM_230_21