Human Bone Marrow‐Derived Mesenchymal Stem Cells Suppress Human Glioma Growth Through Inhibition of Angiogenesis

Tumor tropism of human bone marrow‐derived mesenchymal stem cells (MSC) has been exploited for the delivery of therapeutic genes for anticancer therapy. However, the exact contribution of these cells in the tumor microenvironment remains unknown. In this study, we examined the biological effect of M...

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Bibliographic Details
Published in:	Stem cells (Dayton, Ohio) Vol. 31; no. 1; pp. 146 - 155
Main Authors:	Ho, Ivy A.W., Toh, Han C, Ng, Wai H., Teo, Yuan L., Guo, Chang M., Hui, Kam M., Lam, Paula Y.P.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.01.2013 Oxford University Press
Subjects:	Angiogenesis Animals Astrocytes Biological effects Bone marrow Bone Marrow Cells - physiology Brain Neoplasms - metabolism Brain Neoplasms - therapy Cathepsin B - biosynthesis Cell Line, Tumor Coculture Techniques Down-Regulation Glioma Glioma - pathology Glioma - therapy Human Umbilical Vein Endothelial Cells Humans Interleukin-1beta - biosynthesis Interleukin‐1β Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - physiology Mice Mice, Inbred BALB C Mice, Nude Monoculture Neovascularization, Pathologic Platelet derived growth factor Proto-Oncogene Proteins c-akt - biosynthesis Proto-Oncogene Proteins c-sis - biosynthesis Proto-Oncogene Proteins c-sis - genetics Receptors, Platelet-Derived Growth Factor - biosynthesis Receptors, Platelet-Derived Growth Factor - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Stem cells Tumor Microenvironment Tumors
ISSN:	1066-5099, 1549-4918, 1549-4918
Online Access:	Get full text
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