Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool

ABSTRACT Specification of the cellular hierarchy in the mammary gland involves complex signaling that remains poorly defined. Polycomb group proteins are known to contribute to the maintenance of stem cell identity through epigenetic modifications, leading to stable alterations in gene expression. T...

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Vydané v:	Stem cells (Dayton, Ohio) Ročník 31; číslo 9; s. 1910 - 1920
Hlavní autori:	Michalak, Ewa Malgorzata, Nacerddine, Karim, Pietersen, Alexandra, Beuger, Vincent, Pawlitzky, Inka, Cornelissen‐Steijger, Paulien, Wientjens, Ellen, Tanger, Ellen, Seibler, Jost, van Lohuizen, Maarten, Jonkers, Jos
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Oxford University Press 01.09.2013
Predmet:	Animals Breasts Differentiation Enhancer of Zeste Homolog 2 Protein EZH2 Female Gene expression Gene Knockdown Techniques Luminal cell Mammary Glands, Animal - cytology Mammary Glands, Animal - growth & development Mammary Glands, Animal - metabolism Mammary stem cells Mice Mice, Inbred C57BL Morphogenesis Polycomb Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - metabolism Pregnancy Reproducibility of Results RNA Interference Rodents Stem cells Stem Cells - cytology Stem Cells - metabolism Polycomb Luminal cell Differentiation Mammary stem cells EZH2
ISSN:	1066-5099, 1549-4918, 1549-4918
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