Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment A new genetically tractable model for human cancer associated fibroblasts

We have recently proposed a new model for understanding tumor metabolism, termed: "The Autophagic Tumor Stroma Model of Cancer Metabolism". In this new paradigm, catabolism (autophagy) in the tumor stroma fuels the anabolic growth of aggressive cancer cells. Mechanistically, tumor cells in...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Cancer biology & therapy Ročník 11; číslo 4; s. 383 - 394
Hlavní autoři:	Trimmer, Casey, Sotgia, Federica, Whitaker-Menezes, Diana, Balliet, Renee M., Eaton, Gregory, Martinez-Outschoorn, Ubaldo E., Pavlides, Stephanos, Howell, Anthony, Iozzo, Renato V., Pestell, Richard G., Scherer, Philipp E., Capozza, Franco, Lisanti, Michael P.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Taylor & Francis 15.02.2011 Landes Bioscience
Témata:	Animals Binding Biology Bioscience Calcium Cancer Caveolin 1 - genetics Caveolin 1 - metabolism Caveolin 1 - pharmacology Cell Cell Line, Transformed Cell Line, Tumor Cell Proliferation - drug effects Cycle Female Fibroblasts - drug effects Fibroblasts - metabolism Gene Expression Regulation, Neoplastic - genetics Gene Knockdown Techniques Humans Landes Mice Mice, Nude Mitochondria - enzymology Mitochondria - metabolism Models, Biological Neoplasms - genetics Neoplasms - metabolism Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Organogenesis Oxidative Stress - drug effects Oxidative Stress - genetics Proteins Proteomics Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Research Paper RNA, Small Interfering Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase - pharmacology Tumor Microenvironment - drug effects Tumor Microenvironment - genetics Xenograft Model Antitumor Assays
ISSN:	1538-4047, 1555-8576, 1555-8576
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!