c-Cbl is a critical modulator of the Ron tyrosine kinase receptor

Ron, the receptor tyrosine kinase (RTK) for the macrophage stimulating protein (MSP), activates multiple signaling pathways by recruiting several positive regulators to a multifunctional docking site. Here we show that stimulation by MSP also recruits a negative regulator, the c-Cbl ubiquitin ligase...

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Bibliographic Details
Published in:	Oncogene Vol. 22; no. 24; pp. 3669 - 3679
Main Authors:	Penengo, Lorenza, Rubin, Chanan, Yarden, Yosef, Gaudino, Giovanni
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 12.06.2003 Nature Publishing Nature Publishing Group
Subjects:	Adaptor Proteins, Signal Transducing Apoptosis Biological and medical sciences Cbl protein Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Endocytosis Fundamental and applied biological sciences. Psychology GRB2 Adaptor Protein Grb2 protein Growth factors Human Genetics Humans Internal Medicine Kinases Ligands Macrophages Medicine Medicine & Public Health Molecular and cellular biology MSP protein Oncology original-paper Phosphotyrosine Protein-tyrosine kinase receptors Proteins Proteins - physiology Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-cbl Receptor Protein-Tyrosine Kinases - metabolism Receptors, Cell Surface - metabolism src Homology Domains Tumorigenesis Ubiquitin Ubiquitin - metabolism Ubiquitin-protein ligase Ubiquitin-Protein Ligases Ron Grb2 c-Cbl ubiquitylation c-Cb1 Enzyme Kinase Transferases Biological receptor
ISSN:	0950-9232, 1476-5594
Online Access:	Get full text
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