Follow-up of Blood-Pressure Lowering and Glucose Control in Type 2 Diabetes

In a follow-up study of patients with type 2 diabetes, mortality benefits in those originally assigned to antihypertensive therapy were evident at the end of follow-up, but in-trial glucose differences did not result in long-term benefits in mortality or macrovascular events. Post-trial follow-up st...

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Veröffentlicht in:	The New England journal of medicine Jg. 371; H. 15; S. 1392 - 1406
Hauptverfasser:	Zoungas, Sophia, Chalmers, John, Neal, Bruce, Billot, Laurent, Li, Qiang, Hirakawa, Yoichiro, Arima, Hisatomi, Monaghan, Helen, Joshi, Rohina, Colagiuri, Stephen, Cooper, Mark E, Glasziou, Paul, Grobbee, Diederick, Hamet, Pavel, Harrap, Stephen, Heller, Simon, Lisheng, Liu, Mancia, Giuseppe, Marre, Michel, Matthews, David R, Mogensen, Carl E, Perkovic, Vlado, Poulter, Neil, Rodgers, Anthony, Williams, Bryan, MacMahon, Stephen, Patel, Anushka, Woodward, Mark
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Waltham, MA Massachusetts Medical Society 09.10.2014
Schlagworte:	Antihypertensive Agents - therapeutic use Biological and medical sciences Blood Glucose Blood pressure Cardiovascular disease Confidence intervals Death Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - mortality Diabetes. Impaired glucose tolerance Drug Combinations Drug dosages Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Follow-Up Studies General aspects Gliclazide - administration & dosage Glucose Glycated Hemoglobin - analysis Hemoglobin Humans Hypertension - complications Hypertension - drug therapy Hypoglycemic Agents - administration & dosage Indapamide Indapamide - therapeutic use Kidney diseases Male Medical research Medical sciences Middle Aged Mortality Perindopril - therapeutic use Ratios Risk Factors Vascular diseases Australia Endocrinopathy Prevention Type 2 diabetes Medicine Check Metabolic diseases Arterial pressure Blood pressure Glucose
ISSN:	0028-4793, 1533-4406, 1533-4406
Online-Zugang:	Volltext
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Zusammenfassung:	In a follow-up study of patients with type 2 diabetes, mortality benefits in those originally assigned to antihypertensive therapy were evident at the end of follow-up, but in-trial glucose differences did not result in long-term benefits in mortality or macrovascular events. Post-trial follow-up studies involving patients with diabetes have previously shown long-term beneficial effects of earlier periods of intensive glucose control, but not blood-pressure lowering, on a range of outcomes, including mortality and macrovascular events. 1 – 3 The Epidemiology of Diabetes Interventions and Complications (EDIC) study, an extension of the Diabetes Control and Complications Trial (DCCT) involving young patients with type 1 diabetes and no history of cardiovascular disease, hypertension, or hypercholesterolemia, showed a lower risk of macrovascular events, as well as a sustained benefit with respect to microvascular complications, beyond the period of intensive glucose control. 1 The post-intervention follow-up of the . . .
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1407963