Endothelin-1 down-regulates matrix metalloproteinase 14 and 15 expression in human first trimester trophoblasts via endothelin receptor type B

STUDY QUESTION Does endothelin-1 (ET-1) regulate matrix metalloproteinase (MMP) 14 and 15 production and invasion of human first trimester trophoblasts? SUMMARY ANSWER ET-1 in pathophysiological concentrations down-regulates MMP14 and MMP15 expression via endothelin receptor (ETR) type B and decreas...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Human reproduction (Oxford) Ročník 32; číslo 1; s. 46 - 54
Hlavní autori:	Majali-Martinez, Alejandro, Velicky, Philipp, Pollheimer, Jürgen, Knöfler, Martin, Yung, Hong wa, Burton, Graham J., Tabrizi-Wizsy, Nassim Ghaffari, Lang, Uwe, Hiden, Ursula, Desoye, Gernot, Dieber-Rotheneder, Martina
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Oxford University Press 01.01.2017
Predmet:	Cell Proliferation - drug effects Dose-Response Relationship, Drug Down-Regulation - drug effects Endothelin-1 - pharmacology Female Humans Matrix Metalloproteinase 14 - genetics Matrix Metalloproteinase 14 - metabolism Matrix Metalloproteinase 15 - genetics Matrix Metalloproteinase 15 - metabolism Placenta - drug effects Placenta - metabolism Pregnancy Pregnancy Trimester, First - metabolism Receptor, Endothelin B - genetics Receptor, Endothelin B - metabolism Trophoblasts - drug effects Trophoblasts - metabolism Tumor Necrosis Factor-alpha - pharmacology hypoxia invasion inflammation MMPs pre-eclampsia endothelin-1 trophoblast
ISSN:	0268-1161, 1460-2350
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Buďte prvý, kto okomentuje tento záznam!