TGF-β and the TGF-β Family: Context-Dependent Roles in Cell and Tissue Physiology

The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and differentiation factors, which is encoded by 33 genes in mammals and comprises homo- and heterodimers. This review introduces the reader to the TGF-β family with its complexity of names and biological activit...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in biology Vol. 8; no. 5
Main Authors: Morikawa, Masato, Derynck, Rik, Miyazono, Kohei
Format: Journal Article
Language:English
Published: United States 01.05.2016
Subjects:
Animals
Cell Differentiation
Cell Proliferation
Disease Progression
Fibrosis - metabolism
Fibrosis - pathology
Gene Expression Regulation
Humans
Immune System - metabolism
Mice
Neoplasms - metabolism
Neoplasms - pathology
Phylogeny
Rats
Signal Transduction
Terminology as Topic
Transforming Growth Factor beta - genetics
Transforming Growth Factor beta - immunology
Transforming Growth Factor beta - metabolism
Transforming Growth Factor beta - physiology
Wound Healing
ISSN:1943-0264, 1943-0264
Online Access:Get more information
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Summary:The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and differentiation factors, which is encoded by 33 genes in mammals and comprises homo- and heterodimers. This review introduces the reader to the TGF-β family with its complexity of names and biological activities. It also introduces TGF-β as the best-studied factor among the TGF-β family proteins, with its diversity of roles in the control of cell proliferation and differentiation, wound healing and immune system, and its key roles in pathology, for example, skeletal diseases, fibrosis, and cancer.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a021873