Histone deacetylase 1 and 2 differentially regulate apoptosis by opposing effects on extracellular signal-regulated kinase 1/2

Histone deacetylases (HDACs) are epigenetic regulators that are important for the control of various pathophysiological events. We found that HDAC inhibitors completely abolished transforming growth factor- β 1 (TGF- β 1)-induced apoptosis in AML-12 and primary mouse hepatocytes. Expression of a dom...

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Bibliographic Details
Published in:	Cell death & disease Vol. 1; no. 5; p. e44
Main Authors:	Lei, W-W, Zhang, K-H, Pan, X-C, Wang, D-M, Hu, Y, Yang, Y-N, Song, J-G
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.05.2010 Springer Nature B.V Nature Publishing Group
Subjects:	631/45/607/1164 631/45/607/275 631/80/82/23 Animals Antibodies Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell Line Cell Survival - drug effects Enzyme Activation - drug effects Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - enzymology Histone Deacetylase 1 - metabolism Histone Deacetylase 2 - metabolism Histone Deacetylase Inhibitors - pharmacology Humans Immunology Life Sciences Mice Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors Mitogen-Activated Protein Kinase 3 - metabolism Models, Biological Original original-article Phosphorylation - drug effects Transforming Growth Factor beta1 - pharmacology 1 HDAC2 TGF ERK1/2 HDAC1 apoptosis signalling
ISSN:	2041-4889, 2041-4889
Online Access:	Get full text
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