Epac-Rap signaling reduces oxidative stress in the tubular epithelium

Activation of Rap1 by exchange protein activated by cAMP (Epac) promotes cell adhesion and actin cytoskeletal polarization. Pharmacologic activation of Epac-Rap signaling by the Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP during ischemia-reperfusion (IR) injury reduces renal failure and appl...

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Bibliographic Details

Published in:	Journal of the American Society of Nephrology Vol. 25; no. 7; p. 1474
Main Authors:	Stokman, Geurt, Qin, Yu, Booij, Tijmen H, Ramaiahgari, Sreenivasa, Lacombe, Marie, Dolman, M Emmy M, van Dorenmalen, Kim M A, Teske, Gwendoline J D, Florquin, Sandrine, Schwede, Frank, van de Water, Bob, Kok, Robbert J, Price, Leo S
Format:	Journal Article
Language:	English
Published:	United States 01.07.2014
Subjects:	Animals Cyclic AMP - analogs & derivatives Cyclic AMP - pharmacology Guanine Nucleotide Exchange Factors - drug effects Guanine Nucleotide Exchange Factors - physiology Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - metabolism Male Mice Mice, Inbred C57BL Oxidative Stress Signal Transduction Urothelium - drug effects Urothelium - metabolism
ISSN:	1533-3450, 1533-3450
Online Access:	Get more information
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