Multicenter imaging outcomes study of The Cancer Genome Atlas glioblastoma patient cohort: imaging predictors of overall and progression-free survival

Despite an aggressive therapeutic approach, the prognosis for most patients with glioblastoma (GBM) remains poor. The aim of this study was to determine the significance of preoperative MRI variables, both quantitative and qualitative, with regard to overall and progression-free survival in GBM. We...

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Published in:Neuro-oncology (Charlottesville, Va.) Vol. 17; no. 11; p. 1525
Main Authors: Wangaryattawanich, Pattana, Hatami, Masumeh, Wang, Jixin, Thomas, Ginu, Flanders, Adam, Kirby, Justin, Wintermark, Max, Huang, Erich S, Bakhtiari, Ali Shojaee, Luedi, Markus M, Hashmi, Syed S, Rubin, Daniel L, Chen, James Y, Hwang, Scott N, Freymann, John, Holder, Chad A, Zinn, Pascal O, Colen, Rivka R
Format: Journal Article
Language:English
Published: England 01.11.2015
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Area Under Curve
Brain Neoplasms - mortality
Brain Neoplasms - pathology
Cohort Studies
Databases, Factual
Disease-Free Survival
Female
Glioblastoma - mortality
Glioblastoma - pathology
Humans
Image Interpretation, Computer-Assisted
Kaplan-Meier Estimate
Magnetic Resonance Imaging
Male
Middle Aged
Neuroimaging - methods
Prognosis
Proportional Hazards Models
Retrospective Studies
ROC Curve
Sensitivity and Specificity
Young Adult
overall survival
glioblastoma
imaging
TCGA
progression free survival
ISSN:1523-5866, 1523-5866
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Abstract Despite an aggressive therapeutic approach, the prognosis for most patients with glioblastoma (GBM) remains poor. The aim of this study was to determine the significance of preoperative MRI variables, both quantitative and qualitative, with regard to overall and progression-free survival in GBM. We retrospectively identified 94 untreated GBM patients from the Cancer Imaging Archive who had pretreatment MRI and corresponding patient outcomes and clinical information in The Cancer Genome Atlas. Qualitative imaging assessments were based on the Visually Accessible Rembrandt Images feature-set criteria. Volumetric parameters were obtained of the specific tumor components: contrast enhancement, necrosis, and edema/invasion. Cox regression was used to assess prognostic and survival significance of each image. Univariable Cox regression analysis demonstrated 10 imaging features and 2 clinical variables to be significantly associated with overall survival. Multivariable Cox regression analysis showed that tumor-enhancing volume (P = .03) and eloquent brain involvement (P < .001) were independent prognostic indicators of overall survival. In the multivariable Cox analysis of the volumetric features, the edema/invasion volume of more than 85 000 mm(3) and the proportion of enhancing tumor were significantly correlated with higher mortality (Ps = .004 and .003, respectively). Preoperative MRI parameters have a significant prognostic role in predicting survival in patients with GBM, thus making them useful for patient stratification and endpoint biomarkers in clinical trials.
AbstractList Despite an aggressive therapeutic approach, the prognosis for most patients with glioblastoma (GBM) remains poor. The aim of this study was to determine the significance of preoperative MRI variables, both quantitative and qualitative, with regard to overall and progression-free survival in GBM.BACKGROUNDDespite an aggressive therapeutic approach, the prognosis for most patients with glioblastoma (GBM) remains poor. The aim of this study was to determine the significance of preoperative MRI variables, both quantitative and qualitative, with regard to overall and progression-free survival in GBM.We retrospectively identified 94 untreated GBM patients from the Cancer Imaging Archive who had pretreatment MRI and corresponding patient outcomes and clinical information in The Cancer Genome Atlas. Qualitative imaging assessments were based on the Visually Accessible Rembrandt Images feature-set criteria. Volumetric parameters were obtained of the specific tumor components: contrast enhancement, necrosis, and edema/invasion. Cox regression was used to assess prognostic and survival significance of each image.METHODSWe retrospectively identified 94 untreated GBM patients from the Cancer Imaging Archive who had pretreatment MRI and corresponding patient outcomes and clinical information in The Cancer Genome Atlas. Qualitative imaging assessments were based on the Visually Accessible Rembrandt Images feature-set criteria. Volumetric parameters were obtained of the specific tumor components: contrast enhancement, necrosis, and edema/invasion. Cox regression was used to assess prognostic and survival significance of each image.Univariable Cox regression analysis demonstrated 10 imaging features and 2 clinical variables to be significantly associated with overall survival. Multivariable Cox regression analysis showed that tumor-enhancing volume (P = .03) and eloquent brain involvement (P < .001) were independent prognostic indicators of overall survival. In the multivariable Cox analysis of the volumetric features, the edema/invasion volume of more than 85 000 mm(3) and the proportion of enhancing tumor were significantly correlated with higher mortality (Ps = .004 and .003, respectively).RESULTSUnivariable Cox regression analysis demonstrated 10 imaging features and 2 clinical variables to be significantly associated with overall survival. Multivariable Cox regression analysis showed that tumor-enhancing volume (P = .03) and eloquent brain involvement (P < .001) were independent prognostic indicators of overall survival. In the multivariable Cox analysis of the volumetric features, the edema/invasion volume of more than 85 000 mm(3) and the proportion of enhancing tumor were significantly correlated with higher mortality (Ps = .004 and .003, respectively).Preoperative MRI parameters have a significant prognostic role in predicting survival in patients with GBM, thus making them useful for patient stratification and endpoint biomarkers in clinical trials.CONCLUSIONSPreoperative MRI parameters have a significant prognostic role in predicting survival in patients with GBM, thus making them useful for patient stratification and endpoint biomarkers in clinical trials.
Despite an aggressive therapeutic approach, the prognosis for most patients with glioblastoma (GBM) remains poor. The aim of this study was to determine the significance of preoperative MRI variables, both quantitative and qualitative, with regard to overall and progression-free survival in GBM. We retrospectively identified 94 untreated GBM patients from the Cancer Imaging Archive who had pretreatment MRI and corresponding patient outcomes and clinical information in The Cancer Genome Atlas. Qualitative imaging assessments were based on the Visually Accessible Rembrandt Images feature-set criteria. Volumetric parameters were obtained of the specific tumor components: contrast enhancement, necrosis, and edema/invasion. Cox regression was used to assess prognostic and survival significance of each image. Univariable Cox regression analysis demonstrated 10 imaging features and 2 clinical variables to be significantly associated with overall survival. Multivariable Cox regression analysis showed that tumor-enhancing volume (P = .03) and eloquent brain involvement (P < .001) were independent prognostic indicators of overall survival. In the multivariable Cox analysis of the volumetric features, the edema/invasion volume of more than 85 000 mm(3) and the proportion of enhancing tumor were significantly correlated with higher mortality (Ps = .004 and .003, respectively). Preoperative MRI parameters have a significant prognostic role in predicting survival in patients with GBM, thus making them useful for patient stratification and endpoint biomarkers in clinical trials.
Author Flanders, Adam
Hatami, Masumeh
Kirby, Justin
Luedi, Markus M
Thomas, Ginu
Zinn, Pascal O
Wangaryattawanich, Pattana
Huang, Erich S
Holder, Chad A
Wintermark, Max
Chen, James Y
Colen, Rivka R
Hwang, Scott N
Rubin, Daniel L
Wang, Jixin
Bakhtiari, Ali Shojaee
Freymann, John
Hashmi, Syed S
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  givenname: Pattana
  surname: Wangaryattawanich
  fullname: Wangaryattawanich, Pattana
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
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  givenname: Masumeh
  surname: Hatami
  fullname: Hatami, Masumeh
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
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  givenname: Jixin
  surname: Wang
  fullname: Wang, Jixin
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
– sequence: 4
  givenname: Ginu
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  fullname: Thomas, Ginu
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
– sequence: 5
  givenname: Adam
  surname: Flanders
  fullname: Flanders, Adam
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
– sequence: 6
  givenname: Justin
  surname: Kirby
  fullname: Kirby, Justin
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
– sequence: 7
  givenname: Max
  surname: Wintermark
  fullname: Wintermark, Max
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
– sequence: 8
  givenname: Erich S
  surname: Huang
  fullname: Huang, Erich S
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
– sequence: 9
  givenname: Ali Shojaee
  surname: Bakhtiari
  fullname: Bakhtiari, Ali Shojaee
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
– sequence: 10
  givenname: Markus M
  surname: Luedi
  fullname: Luedi, Markus M
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
– sequence: 11
  givenname: Syed S
  surname: Hashmi
  fullname: Hashmi, Syed S
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
– sequence: 12
  givenname: Daniel L
  surname: Rubin
  fullname: Rubin, Daniel L
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
– sequence: 13
  givenname: James Y
  surname: Chen
  fullname: Chen, James Y
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
– sequence: 14
  givenname: Scott N
  surname: Hwang
  fullname: Hwang, Scott N
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
– sequence: 15
  givenname: John
  surname: Freymann
  fullname: Freymann, John
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
– sequence: 16
  givenname: Chad A
  surname: Holder
  fullname: Holder, Chad A
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
– sequence: 17
  givenname: Pascal O
  surname: Zinn
  fullname: Zinn, Pascal O
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
– sequence: 18
  givenname: Rivka R
  surname: Colen
  fullname: Colen, Rivka R
  organization: Departments of Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.W., M.H., J.W., G.T., A.S.B., M.M.L., R.R.C.); Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (P.W.); Department of Radiology, Division of Neuroradiology/ENT, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania (A.F.); Bioinformatics Analyst III, Clinical Monitoring Research Program (CMRP), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Rockville, Maryland (J.K.); Department of Radiology, Neuroradiology Division, Stanford University, Stanford, California (M.W.); Cancer Research, Sage Bionetworks, Seattle, Washington (E.S.H.); Department of Diagnostic and Interventional Imaging, University of Texas Health Sciences Center, Houston, Texas (S.S.H.); Department of Radiology, Stanford University, Stanford, California (D.L.R.); Department of Radiology, University of California San Diego, San Diego, California (J.Y.C.); Neuroradiology Section, St Jude Children's Research Hospital, Memphis, Tennessee (S.N.H.); Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Rockville, Maryland (J.F.); Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia (C.A.H.); Department of Neurosurgery, Baylor College of Medicine, Houston, Texas (P.O.Z.); Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Houston, Texas (P.O.Z.); Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas (R.R.C.)
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Copyright The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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Issue 11
Keywords overall survival
glioblastoma
imaging
TCGA
progression free survival
Language English
License The Author(s) 2015. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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PublicationTitle Neuro-oncology (Charlottesville, Va.)
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PublicationYear 2015
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– reference: 8699228 - J Neurooncol. 1996 Jan;27(1):65-73
– reference: 24997477 - J Neuroradiol. 2015 Jul;42(4):212-21
– reference: 6308989 - AJNR Am J Neuroradiol. 1983 May-Jun;4(3):488-90
– reference: 23392431 - Radiology. 2013 May;267(2):560-9
– reference: 16361543 - Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8600-5
– reference: 10433106 - J Neurooncol. 1999 May;42(3):227-31
– reference: 18772890 - Nature. 2008 Oct 23;455(7216):1061-8
– reference: 21997991 - Radiographics. 2011 Oct;31(6):1717-40
– reference: 15758010 - N Engl J Med. 2005 Mar 10;352(10):997-1003
– reference: 17889341 - Acad Radiol. 2007 Oct;14(10):1242-51
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– reference: 10570440 - Cancer. 1999 Nov 15;86(10):2117-23
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Snippet Despite an aggressive therapeutic approach, the prognosis for most patients with glioblastoma (GBM) remains poor. The aim of this study was to determine the...
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StartPage 1525
SubjectTerms Adolescent
Adult
Aged
Aged, 80 and over
Area Under Curve
Brain Neoplasms - mortality
Brain Neoplasms - pathology
Cohort Studies
Databases, Factual
Disease-Free Survival
Female
Glioblastoma - mortality
Glioblastoma - pathology
Humans
Image Interpretation, Computer-Assisted
Kaplan-Meier Estimate
Magnetic Resonance Imaging
Male
Middle Aged
Neuroimaging - methods
Prognosis
Proportional Hazards Models
Retrospective Studies
ROC Curve
Sensitivity and Specificity
Young Adult
Title Multicenter imaging outcomes study of The Cancer Genome Atlas glioblastoma patient cohort: imaging predictors of overall and progression-free survival
URI https://www.ncbi.nlm.nih.gov/pubmed/26203066
https://www.proquest.com/docview/1721353494
Volume 17
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