Multicenter imaging outcomes study of The Cancer Genome Atlas glioblastoma patient cohort: imaging predictors of overall and progression-free survival

Despite an aggressive therapeutic approach, the prognosis for most patients with glioblastoma (GBM) remains poor. The aim of this study was to determine the significance of preoperative MRI variables, both quantitative and qualitative, with regard to overall and progression-free survival in GBM. We...

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Vydané v:Neuro-oncology (Charlottesville, Va.) Ročník 17; číslo 11; s. 1525
Hlavní autori: Wangaryattawanich, Pattana, Hatami, Masumeh, Wang, Jixin, Thomas, Ginu, Flanders, Adam, Kirby, Justin, Wintermark, Max, Huang, Erich S, Bakhtiari, Ali Shojaee, Luedi, Markus M, Hashmi, Syed S, Rubin, Daniel L, Chen, James Y, Hwang, Scott N, Freymann, John, Holder, Chad A, Zinn, Pascal O, Colen, Rivka R
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England 01.11.2015
Predmet:
Adolescent
Adult
Aged
Aged, 80 and over
Area Under Curve
Brain Neoplasms - mortality
Brain Neoplasms - pathology
Cohort Studies
Databases, Factual
Disease-Free Survival
Female
Glioblastoma - mortality
Glioblastoma - pathology
Humans
Image Interpretation, Computer-Assisted
Kaplan-Meier Estimate
Magnetic Resonance Imaging
Male
Middle Aged
Neuroimaging - methods
Prognosis
Proportional Hazards Models
Retrospective Studies
ROC Curve
Sensitivity and Specificity
Young Adult
overall survival
glioblastoma
imaging
TCGA
progression free survival
ISSN:1523-5866, 1523-5866
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Shrnutí:Despite an aggressive therapeutic approach, the prognosis for most patients with glioblastoma (GBM) remains poor. The aim of this study was to determine the significance of preoperative MRI variables, both quantitative and qualitative, with regard to overall and progression-free survival in GBM. We retrospectively identified 94 untreated GBM patients from the Cancer Imaging Archive who had pretreatment MRI and corresponding patient outcomes and clinical information in The Cancer Genome Atlas. Qualitative imaging assessments were based on the Visually Accessible Rembrandt Images feature-set criteria. Volumetric parameters were obtained of the specific tumor components: contrast enhancement, necrosis, and edema/invasion. Cox regression was used to assess prognostic and survival significance of each image. Univariable Cox regression analysis demonstrated 10 imaging features and 2 clinical variables to be significantly associated with overall survival. Multivariable Cox regression analysis showed that tumor-enhancing volume (P = .03) and eloquent brain involvement (P < .001) were independent prognostic indicators of overall survival. In the multivariable Cox analysis of the volumetric features, the edema/invasion volume of more than 85 000 mm(3) and the proportion of enhancing tumor were significantly correlated with higher mortality (Ps = .004 and .003, respectively). Preoperative MRI parameters have a significant prognostic role in predicting survival in patients with GBM, thus making them useful for patient stratification and endpoint biomarkers in clinical trials.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-5866
1523-5866
DOI:10.1093/neuonc/nov117